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1TMK
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BU of 1tmk by Molmil
YEAST THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (DTMP)
Descriptor: SULFATE ION, THYMIDINE-5'-PHOSPHATE, THYMIDYLATE KINASE
Authors:Lavie, A, Schlichting, I.
Deposit date:1997-06-12
Release date:1998-06-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation.
Nat.Struct.Biol., 4, 1997
1XYA
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BU of 1xya by Molmil
X-RAY CRYSTALLOGRAPHIC STRUCTURES OF D-XYLOSE ISOMERASE-SUBSTRATE COMPLEXES POSITION THE SUBSTRATE AND PROVIDE EVIDENCE FOR METAL MOVEMENT DURING CATALYSIS
Descriptor: HYDROXIDE ION, MAGNESIUM ION, XYLOSE ISOMERASE
Authors:Lavie, A, Allen, K.N, Petsko, G.A, Ringe, D.
Deposit date:1994-01-03
Release date:1994-05-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.
Biochemistry, 33, 1994
1XYC
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BU of 1xyc by Molmil
X-RAY CRYSTALLOGRAPHIC STRUCTURES OF D-XYLOSE ISOMERASE-SUBSTRATE COMPLEXES POSITION THE SUBSTRATE AND PROVIDE EVIDENCE FOR METAL MOVEMENT DURING CATALYSIS
Descriptor: 3-O-METHYLFRUCTOSE IN LINEAR FORM, MAGNESIUM ION, XYLOSE ISOMERASE
Authors:Lavie, A, Allen, K.N, Petsko, G.A, Ringe, D.
Deposit date:1994-01-03
Release date:1994-05-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.
Biochemistry, 33, 1994
1XYB
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BU of 1xyb by Molmil
X-RAY CRYSTALLOGRAPHIC STRUCTURES OF D-XYLOSE ISOMERASE-SUBSTRATE COMPLEXES POSITION THE SUBSTRATE AND PROVIDE EVIDENCE FOR METAL MOVEMENT DURING CATALYSIS
Descriptor: D-glucose, MAGNESIUM ION, XYLOSE ISOMERASE
Authors:Lavie, A, Allen, K.N, Petsko, G.A, Ringe, D.
Deposit date:1994-01-03
Release date:1994-05-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.
Biochemistry, 33, 1994
5TMP
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BU of 5tmp by Molmil
COMPLEX OF E. COLI THYMIDYLATE KINASE WITH THE BISUBSTRATE INHIBITOR AZTP5A
Descriptor: P1-(5'-ADENOSYL)P5-(5'-(3'AZIDO-3'-DEOXYTHYMIDYL))PENTAPHOSPHATE, PROTEIN (THYMIDYLATE KINASE)
Authors:Lavie, A, Ostermann, N, Schlichting, I.
Deposit date:1998-09-01
Release date:1998-11-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase.
Proc.Natl.Acad.Sci.USA, 95, 1998
2TMK
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BU of 2tmk by Molmil
YEAST THYMIDYLATE KINASE COMPLEXED WITH 3'-AZIDO-3'-DEOXYTHYMIDINE MONOPHOSPHATE (AZT-MP)
Descriptor: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, SULFATE ION, THYMIDYLATE KINASE
Authors:Lavie, A, Schlichting, I.
Deposit date:1997-06-12
Release date:1998-06-17
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation.
Nat.Struct.Biol., 4, 1997
3TMK
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BU of 3tmk by Molmil
CRYSTAL STRUCTURE OF YEAST THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR TP5A AT 2.0 A RESOLUTION: IMPLICATIONS FOR CATALYSIS AND AZT ACTIVATION
Descriptor: P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, THYMIDYLATE KINASE
Authors:Lavie, A, Schlichting, I, Konrad, M, Goody, R.S, Brundiers, R, Reinstein, J.
Deposit date:1998-01-26
Release date:1999-02-16
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation.
Biochemistry, 37, 1998
4TMK
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BU of 4tmk by Molmil
COMPLEX OF E. COLI THYMIDYLATE KINASE WITH THE BISUBSTRATE INHIBITOR TP5A
Descriptor: P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, PROTEIN (THYMIDYLATE KINASE)
Authors:Lavie, A, Ostermann, N, Schlichting, I.
Deposit date:1998-08-31
Release date:1998-11-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase.
Proc.Natl.Acad.Sci.USA, 95, 1998
7U6M
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BU of 7u6m by Molmil
Albumin binding domain fused to a mutant of the Erwinia asparaginase
Descriptor: ASPARTIC ACID, L-asparaginase
Authors:Lavie, A, Nguyen, H.A.
Deposit date:2022-03-04
Release date:2022-08-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia.
Haematologica, 108, 2023
3MTR
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BU of 3mtr by Molmil
Crystal structure of the Ig5-FN1 tandem of human NCAM
Descriptor: Neural cell adhesion molecule 1, SULFATE ION
Authors:Lavie, A, Foley, D.A.
Deposit date:2010-04-30
Release date:2010-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and mutagenesis of neural cell adhesion molecule domains: evidence for flexibility in the placement of polysialic acid attachment sites
J.Biol.Chem., 285, 2010
3QEN
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BU of 3qen by Molmil
S74E dCK in complex with 5-bromodeoxycytidine and UDP
Descriptor: 5-bromo-2'-deoxycytidine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
Authors:Lavie, A, Hazra, S.
Deposit date:2011-01-20
Release date:2011-03-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Biochemistry, 50, 2011
3QEO
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BU of 3qeo by Molmil
S74E-R104M-D133A dCK variant in complex with L-deoxythymidine and UDP
Descriptor: Deoxycytidine kinase, L-deoxythymidine, URIDINE-5'-DIPHOSPHATE
Authors:Lavie, A, Hazra, S.
Deposit date:2011-01-20
Release date:2011-03-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.897 Å)
Cite:Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Biochemistry, 50, 2011
2RCZ
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BU of 2rcz by Molmil
Structure of the second PDZ domain of ZO-1
Descriptor: Tight junction protein ZO-1
Authors:Lavie, A, Lye, M.F.
Deposit date:2007-09-20
Release date:2007-10-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Domain swapping within PDZ2 is responsible for dimerization of ZO proteins.
J.Biol.Chem., 282, 2007
6VMZ
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BU of 6vmz by Molmil
Crystal Structure of a H5N1 influenza virus hemagglutinin with CBS1117
Descriptor: 2,6-dichloro-N-[1-(propan-2-yl)piperidin-4-yl]benzamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin
Authors:Antanasijevic, A, Durst, M.A, Lavie, A, Caffrey, M.
Deposit date:2020-01-28
Release date:2020-07-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of avian influenza hemagglutinin in complex with a small molecule entry inhibitor.
Life Sci Alliance, 3, 2020
6PCX
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BU of 6pcx by Molmil
Crystal Structure of a H5N1 influenza virus hemagglutinin at pH 6.0
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Hemagglutinin, ...
Authors:Antanasijevic, A, Durst, M.A, Lavie, A, Caffrey, M.
Deposit date:2019-06-18
Release date:2019-11-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Identification of a pH sensor in Influenza hemagglutinin using X-ray crystallography.
J.Struct.Biol., 209, 2020
3KFX
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BU of 3kfx by Molmil
Human dCK complex with 5-Me dC and ADP
Descriptor: 5-METHYL-2'-DEOXYCYTIDINE, ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase
Authors:Hazra, S, Lavie, A.
Deposit date:2009-10-28
Release date:2010-09-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues .
Biochemistry, 49, 2010
2A2Z
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BU of 2a2z by Molmil
Crystal Structure of human deoxycytidine kinase in complex with deoxycytidine and uridine diphosphate
Descriptor: 2'-DEOXYCYTIDINE, CALCIUM ION, Deoxycytidine kinase, ...
Authors:Godsey, M.H, Ort, S, Sabini, E, Konrad, M, Lavie, A.
Deposit date:2005-06-23
Release date:2006-01-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization.
Biochemistry, 45, 2006
2GYI
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BU of 2gyi by Molmil
DESIGN, SYNTHESIS, AND CHARACTERIZATION OF A POTENT XYLOSE ISOMERASE INHIBITOR, D-THREONOHYDROXAMIC ACID, AND HIGH-RESOLUTION X-RAY CRYSTALLOGRAPHIC STRUCTURE OF THE ENZYME-INHIBITOR COMPLEX
Descriptor: 2,3,4,N-TETRAHYDROXY-BUTYRIMIDIC ACID, MAGNESIUM ION, XYLOSE ISOMERASE
Authors:Allen, K.N, Lavie, A, Petsko, G.A, Ringe, D.
Deposit date:1994-09-01
Release date:1995-07-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Design, Synthesis, and Characterization of a Potent Xylose Isomerase Inhibitor, D-Threonohydroxamic Acid, and High-Resolution X-Ray Crystallographic Structure of the Enzyme-Inhibitor Complex
Biochemistry, 34, 1995
4YYX
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BU of 4yyx by Molmil
Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin2 C-terminal tail
Descriptor: FORMIC ACID, Tight junction protein ZO-1 fused with Claudin-2 C-terminal
Authors:Nomme, J, Lavie, A.
Deposit date:2015-03-24
Release date:2015-04-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural Basis of a Key Factor Regulating the Affinity between the Zonula Occludens First PDZ Domain and Claudins.
J.Biol.Chem., 290, 2015
6AQB
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BU of 6aqb by Molmil
Structure of the SH3 domain of MLK3 bound to peptide generated from phage display
Descriptor: 1,2-ETHANEDIOL, Chimera protein of MLK3-SH3 and MIP (E.C.2.7.11.25), PHOSPHATE ION
Authors:Kall, S.K, Lavie, A.
Deposit date:2017-08-19
Release date:2018-07-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3.
J. Biol. Chem., 293, 2018
6OC0
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BU of 6oc0 by Molmil
Crystal structure of human DHODH with OSU-03012
Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Durst, M.A, Lavie, A.
Deposit date:2019-03-21
Release date:2019-11-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism.
Cell Chem Biol, 27, 2020
6OC1
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BU of 6oc1 by Molmil
Crystal structure of human DHODH with TAK-632
Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Durst, M.A, Lavie, A.
Deposit date:2019-03-21
Release date:2019-11-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism.
Cell Chem Biol, 27, 2020
1KGD
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BU of 1kgd by Molmil
Crystal Structure of the Guanylate Kinase-like Domain of Human CASK
Descriptor: FORMIC ACID, PERIPHERAL PLASMA MEMBRANE CASK
Authors:Li, Y, Spangenberg, O, Paarmann, I, Konrad, M, Lavie, A.
Deposit date:2001-11-26
Release date:2001-12-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.314 Å)
Cite:Structural basis for nucleotide-dependent regulation of membrane-associated guanylate kinase-like domains.
J.Biol.Chem., 277, 2002
1XYM
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BU of 1xym by Molmil
THE ROLE OF THE DIVALENT METAL ION IN SUGAR BINDING, RING OPENING, AND ISOMERIZATION BY D-XYLOSE ISOMERASE: REPLACEMENT OF A CATALYTIC METAL BY AN AMINO-ACID
Descriptor: D-glucose, HYDROXIDE ION, MAGNESIUM ION, ...
Authors:Allen, K.N, Lavie, A, Petsko, G.A, Ringe, D.
Deposit date:1993-12-07
Release date:1994-05-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid.
Biochemistry, 33, 1994
1XYL
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BU of 1xyl by Molmil
THE ROLE OF THE DIVALENT METAL ION IN SUGAR BINDING, RING OPENING, AND ISOMERIZATION BY D-XYLOSE ISOMERASE: REPLACEMENT OF A CATALYTIC METAL BY AN AMINO-ACID
Descriptor: HYDROXIDE ION, MAGNESIUM ION, XYLOSE ISOMERASE
Authors:Allen, K.N, Lavie, A, Petsko, G.A, Ringe, D.
Deposit date:1993-12-07
Release date:1994-05-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid.
Biochemistry, 33, 1994

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