4TMK

COMPLEX OF E. COLI THYMIDYLATE KINASE WITH THE BISUBSTRATE INHIBITOR TP5A

Summary for 4TMK

Entry DOI	10.2210/pdb4tmk/pdb
Descriptor	PROTEIN (THYMIDYLATE KINASE), P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE (3 entities in total)
Functional Keywords	atp:dtmp phosphotransferase, transferase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	24719.51
Authors	Lavie, A.,Ostermann, N.,Schlichting, I. (deposition date: 1998-08-31, release date: 1998-11-25, Last modification date: 2023-12-27)
Primary citation	Lavie, A.,Ostermann, N.,Brundiers, R.,Goody, R.S.,Reinstein, J.,Konrad, M.,Schlichting, I. Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase. Proc.Natl.Acad.Sci.USA, 95:14045-14050, 1998 Cited by PubMed: 9826650 DOI: 10.1073/pnas.95.24.14045 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation