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4TMK

COMPLEX OF E. COLI THYMIDYLATE KINASE WITH THE BISUBSTRATE INHIBITOR TP5A

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004798molecular_functiondTMP kinase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006227biological_processdUDP biosynthetic process
A0006233biological_processdTDP biosynthetic process
A0006235biological_processdTTP biosynthetic process
A0009165biological_processnucleotide biosynthetic process
A0015949biological_processnucleobase-containing small molecule interconversion
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0042803molecular_functionprotein homodimerization activity
Functional Information from PDB Data
site_idAC1
Number of Residues37
DetailsBINDING SITE FOR RESIDUE T5A A 214
ChainResidue
AGLU12
AGLU25
AARG39
AGLU40
AARG51
ALEU55
APHE74
AARG78
AARG100
ASER104
ATHR105
AGLY13
ATYR108
AGLN109
AARG149
AARG153
AASP157
AILE159
AHOH1013
AHOH1025
AHOH1026
AHOH1027
AALA14
AHOH1028
AHOH1030
AHOH1036
AHOH1037
AHOH1038
AHOH1050
AHOH1052
AHOH1066
AGLY15
ALYS16
ATHR17
ATHR17
AARG20
AASN21

Functional Information from PROSITE/UniProt
site_idPS01331
Number of Residues13
DetailsTHYMIDYLATE_KINASE Thymidylate kinase signature. IGDRHdlSTqAYQ
ChainResidueDetails
AILE97-GLN109

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsRegion: {"description":"LID"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues13
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"9826650","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsSite: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"9826650","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

244693

PDB entries from 2025-11-12

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