3TMK

CRYSTAL STRUCTURE OF YEAST THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR TP5A AT 2.0 A RESOLUTION: IMPLICATIONS FOR CATALYSIS AND AZT ACTIVATION

Summary for 3TMK

Entry DOI	10.2210/pdb3tmk/pdb
Descriptor	THYMIDYLATE KINASE, P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE (3 entities in total)
Functional Keywords	kinase, phosphotransferase
Biological source	Saccharomyces cerevisiae (baker's yeast)
Total number of polymer chains	8
Total formula weight	204885.83
Authors	Lavie, A.,Schlichting, I.,Konrad, M.,Goody, R.S.,Brundiers, R.,Reinstein, J. (deposition date: 1998-01-26, release date: 1999-02-16, Last modification date: 2023-08-09)
Primary citation	Lavie, A.,Konrad, M.,Brundiers, R.,Goody, R.S.,Schlichting, I.,Reinstein, J. Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation. Biochemistry, 37:3677-3686, 1998 Cited by PubMed: 9521686 DOI: 10.1021/bi9720787 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation