3TMK

CRYSTAL STRUCTURE OF YEAST THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR TP5A AT 2.0 A RESOLUTION: IMPLICATIONS FOR CATALYSIS AND AZT ACTIVATION

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	THYMIDYLATE KINASE	polymer	216	24719.4	8	UniProt (P00572) Pfam (PF02223)	Saccharomyces cerevisiae (baker's yeast)
2	I, J, K, L, M... (A, B, C, D, E...)	P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE	non-polymer		891.4	8	Chemie (T5A)
3	Q, R, S, T, U... (A, B, C, D, E...)	water	water		18.0	1088	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	197755.0
Non-Polymers*	Number of molecules	8
	Total formula weight	7130.8
All*	Total formula weight	204885.8

*Water molecules are not included.