4YYX

Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin2 C-terminal tail

Replaces:  4OEQ

Summary for 4YYX

• Entry DOI: 10.2210/pdb4yyx/pdb
• Related: 4OEO 4OEP
• Descriptor: Tight junction protein ZO-1 fused with Claudin-2 C-terminal, FORMIC ACID (3 entities in total)
• Functional Keywords: tight junction, maguk, pdz1, scaffolding, cell adhesion, claudin
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 23133.99

Authors

Nomme, J.,Lavie, A. (deposition date: 2015-03-24, release date: 2015-04-01, Last modification date: 2023-09-27)

• Primary citation: Nomme, J.,Antanasijevic, A.,Caffrey, M.,Van Itallie, C.M.,Anderson, J.M.,Fanning, A.S.,Lavie, A.; Structural Basis of a Key Factor Regulating the Affinity between the Zonula Occludens First PDZ Domain and Claudins.; J.Biol.Chem., 290:16595-16606, 2015; PubMed: 26023235; DOI: 10.1074/jbc.M115.646695

Experimental method

X-RAY DIFFRACTION (1.79 Å)