4YYX

Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin2 C-terminal tail

Replaces:  4OEQ

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tight junction protein ZO-1 fused with Claudin-2 C-terminal	polymer	107	11521.0	2	UniProt (Q07157) UniProt (P57739) Pfam (PF00595)	Homo sapiens (Human)	Tight junction protein 1,Zona occludens protein 1,Zonula occludens protein 1,SP82
2	C, D (A, B)	FORMIC ACID	non-polymer		46.0	2	Chemie (FMT)
3	E, F (A, B)	water	water		18.0	187	Chemie (HOH)

Sequence modifications

A, B: 18 - 110 (UniProt: Q07157)

PDB	External Database	Details
Gly 14	-	expression tag
Ser 15	-	expression tag
His 16	-	expression tag
Met 17	-	expression tag
Gly 111	-	linker
Gly 112	-	linker
Gly 113	-	linker

A, B: 114 - 120 (UniProt: P57739)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	23041.9
Non-Polymers*	Number of molecules	2
	Total formula weight	92.0
All*	Total formula weight	23134.0

*Water molecules are not included.