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4YYX

Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin2 C-terminal tail

Replaces:  4OEQ
Functional Information from GO Data
ChainGOidnamespacecontents
A0005923cellular_componentbicellular tight junction
B0005923cellular_componentbicellular tight junction
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue FMT A 201
ChainResidue
AMET77
AASN79
AGLY80
ALYS103
ATHR105

site_idAC2
Number of Residues7
Detailsbinding site for residue FMT B 201
ChainResidue
BTHR105
BHOH304
BHOH352
BMET77
BASN79
BGLY80
BLYS103

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsRegion: {"description":"Interactions with TJP1, TJP2 and TJP3","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues174
DetailsDomain: {"description":"PDZ 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00143","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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