3QEO
S74E-R104M-D133A dCK variant in complex with L-deoxythymidine and UDP
Summary for 3QEO
Entry DOI | 10.2210/pdb3qeo/pdb |
Related | 3QEJ 3QEN |
Descriptor | Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE, L-deoxythymidine, ... (4 entities in total) |
Functional Keywords | alpha/beta, phosphoryl transfer, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P27707 |
Total number of polymer chains | 2 |
Total formula weight | 66381.86 |
Authors | |
Primary citation | Hazra, S.,Szewczak, A.,Ort, S.,Konrad, M.,Lavie, A. Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release. Biochemistry, 50:2870-2880, 2011 Cited by PubMed: 21351740DOI: 10.1021/bi2001032 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.897 Å) |
Structure validation
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