2GYI

DESIGN, SYNTHESIS, AND CHARACTERIZATION OF A POTENT XYLOSE ISOMERASE INHIBITOR, D-THREONOHYDROXAMIC ACID, AND HIGH-RESOLUTION X-RAY CRYSTALLOGRAPHIC STRUCTURE OF THE ENZYME-INHIBITOR COMPLEX

Replaces:  1GYI

Summary for 2GYI

• Entry DOI: 10.2210/pdb2gyi/pdb
• Descriptor: XYLOSE ISOMERASE, MAGNESIUM ION, 2,3,4,N-TETRAHYDROXY-BUTYRIMIDIC ACID, ... (4 entities in total)
• Functional Keywords: isomerase(intramolecular oxidoreductase)
• Biological source: Streptomyces olivochromogenes
• Cellular location: Cytoplasm: P15587
• Total number of polymer chains: 2
• Total formula weight: 86089.15

Authors

Allen, K.N.,Lavie, A.,Petsko, G.A.,Ringe, D. (deposition date: 1994-09-01, release date: 1995-07-10, Last modification date: 2024-02-14)

• Primary citation: Allen, K.N.,Lavie, A.,Petsko, G.A.,Ringe, D.; Design, Synthesis, and Characterization of a Potent Xylose Isomerase Inhibitor, D-Threonohydroxamic Acid, and High-Resolution X-Ray Crystallographic Structure of the Enzyme-Inhibitor Complex; Biochemistry, 34:3742-3749, 1995; PubMed: 7893671; DOI: 10.1021/bi00011a032

Experimental method

X-RAY DIFFRACTION (1.6 Å)