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8T2V
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Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A.
登録日2023-06-06
公開日2023-07-26
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids.
Nat Commun, 14, 2023
1JV2
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Xiong, J.P, Stehle, T, Diefenbach, B, Zhang, R, Dunker, R, Scott, D, Joachimiak, A, Goodman, S.L, Arnaout, M.A.
登録日2001-08-28
公開日2001-10-17
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal structure of the extracellular segment of integrin alpha Vbeta3.
Science, 294, 2001
1L5G
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN AVB3 IN COMPLEX WITH AN ARG-GLY-ASP LIGAND
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Xiong, J.-P, Stehle, T, Zhang, R, Joachimiak, A, Frech, M, Goodman, S.L, Arnaout, M.A.
登録日2002-03-06
公開日2002-04-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.
Science, 296, 2002
6MK0
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Integrin AlphaVBeta3 ectodomain bound to antagonist TDI-4161
分子名称: (2S)-2-[(1,3-benzothiazole-2-carbonyl)amino]-4-{[5-(1,8-naphthyridin-2-yl)pentanoyl]amino}butanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者van Agthoven, J, Arnaout, M.A.
登録日2018-09-24
公開日2019-09-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.005 Å)
主引用文献Novel Pure alphaVbeta3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations
Acs Pharmacol Transl Sci, 2, 2019
1M1X
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Xiong, J.-P, Stehle, T, Zhang, R, Joachimiak, A, Frech, M, Goodman, S.L, Arnaout, M.A.
登録日2002-06-20
公開日2002-08-14
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.
Science, 296, 2002
6MSL
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Integrin AlphaVBeta3 ectodomain bound to EETI-II 2.5D
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cystine Knot Protein 2.5D, ...
著者van Agthoven, J.F, Arnaout, M.A.
登録日2018-10-16
公開日2019-10-23
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.104 Å)
主引用文献Structural Basis of the Differential Binding of Engineered Knottins to Integrins alpha V beta 3 and alpha 5 beta 1.
Structure, 27, 2019
6MSU
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Integrin alphaVBeta3 in complex with EETI-II 2.5F
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
著者van Agthoven, J.F, Arnaout, M.A.
登録日2018-10-18
公開日2019-10-23
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Structural Basis of the Differential Binding of Engineered Knottins to Integrins alpha V beta 3 and alpha 5 beta 1.
Structure, 27, 2019
6UJA
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Integrin alpha-v beta-8 in complex with pro-TGF-beta1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L.
登録日2019-10-02
公開日2020-02-05
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta.
Cell, 180, 2020
6UJC
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Integrin alpha-v beta-8 in complex with the Fabs C6-RGD3 and 11D12v2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C6-RGD3 heavy chain Fab, ...
著者Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L.
登録日2019-10-02
公開日2020-02-05
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.56 Å)
主引用文献Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta.
Cell, 180, 2020
6UJB
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Integrin alpha-v beta-8 in complex with the Fabs C6D4 and 11D12v2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C6D4 heavy chain Fab, ...
著者Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L.
登録日2019-10-02
公開日2020-02-05
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.51 Å)
主引用文献Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta.
Cell, 180, 2020
6V4P
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Structure of the integrin AlphaIIbBeta3-Abciximab complex
分子名称: Abciximab, heavy chain, light chain, ...
著者Nesic, D, Zhang, Y, Spasic, A, Li, J, Provasi, D, Filizola, M, Walz, T, Coller, B.S.
登録日2019-11-28
公開日2020-02-05
最終更新日2020-03-11
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Cryo-Electron Microscopy Structure of the alpha IIb beta 3-Abciximab Complex.
Arterioscler Thromb Vasc Biol., 40, 2020
2WG3
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BU of 2wg3 by Molmil
Crystal structure of the complex between human hedgehog-interacting protein HIP and desert hedgehog without calcium
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DESERT HEDGEHOG PROTEIN N-PRODUCT, ...
著者Bishop, B, Aricescu, A.R, Harlos, K, O'Callaghan, C.A, Jones, E.Y, Siebold, C.
登録日2009-04-15
公開日2009-06-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip
Nat.Struct.Mol.Biol., 16, 2009
2WFX
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Crystal structure of the complex between human hedgehog-interacting protein HIP and Sonic Hedgehog in the presence of calcium
分子名称: CALCIUM ION, HEDGEHOG-INTERACTING PROTEIN, SODIUM ION, ...
著者Bishop, B, Aricescu, A.R, Harlos, K, O'Callaghan, C.A, Jones, E.Y, Siebold, C.
登録日2009-04-15
公開日2009-06-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip
Nat.Struct.Mol.Biol., 16, 2009
2WG4
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Crystal structure of the complex between human hedgehog-interacting protein HIP and sonic hedgehog without calcium
分子名称: HEDGEHOG-INTERACTING PROTEIN, SODIUM ION, SONIC HEDGEHOG PROTEIN N-PRODUCT, ...
著者Bishop, B, Aricescu, A.R, Harlos, K, O'Callaghan, C.A, Jones, E.Y, Siebold, C.
登録日2009-04-15
公開日2009-06-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip
Nat.Struct.Mol.Biol., 16, 2009
4MMX
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Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ...
著者van Agthoven, J, Xiong, J, Arnaout, M.A.
登録日2013-09-09
公開日2014-03-26
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.32 Å)
主引用文献Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin.
Nat.Struct.Mol.Biol., 21, 2014
4MMY
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Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin with the IAKGDWND motif
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ...
著者van Agthoven, J, Xiong, J, Arnaout, M.A.
登録日2013-09-09
公開日2014-03-26
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.183 Å)
主引用文献Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin.
Nat.Struct.Mol.Biol., 21, 2014
4MMZ
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Integrin AlphaVBeta3 ectodomain bound to an antagonistic tenth domain of Fibronectin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ...
著者van Agthoven, J, Xiong, J, Arnaout, M.A.
登録日2013-09-09
公開日2014-03-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin.
Nat.Struct.Mol.Biol., 21, 2014
4O02
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AlphaVBeta3 integrin in complex with monoclonal antibody FAB fragment.
分子名称: 17E6 heavy chain, 17E6 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Mahalingam, B, van Agthoven, J, Xiong, J, Arnaout, M.A.
登録日2013-12-13
公開日2014-04-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.605 Å)
主引用文献Atomic basis for the species-specific inhibition of alpha V integrins by monoclonal antibody 17E6 is revealed by the crystal structure of alpha V beta 3 ectodomain-17E6 Fab complex.
J.Biol.Chem., 289, 2014
3G5C
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Structural and biochemical studies on the ectodomain of human ADAM22
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADAM 22, CALCIUM ION
著者Liu, H, Shim, A, Chen, X, He, X.
登録日2009-02-04
公開日2009-08-18
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Structural and biochemical studies on the ectodomain of human ADAM22
J.Biol.Chem., 2009
3HO5
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Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex
分子名称: CALCIUM ION, Hedgehog-interacting protein, Sonic hedgehog protein, ...
著者Hymowitz, S.G, Bosanac, I.
登録日2009-06-01
公開日2009-06-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Nat.Struct.Mol.Biol., 16, 2009
3IJE
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Crystal structure of the complete integrin alhaVbeta3 ectodomain plus an Alpha/beta transmembrane fragment
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Xiong, J.-P, Mahalingham, B, Rui, X, Hyman, B.T, Goodman, S.L, Arnaout, M.A.
登録日2009-08-04
公開日2009-09-29
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment.
J.Cell Biol., 186, 2009
5Y31
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Crystal structure of human LGI1-ADAM22 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 22, ...
著者Yamagata, A, Fukai, S.
登録日2017-07-27
公開日2018-05-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (7.125 Å)
主引用文献Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
Nat Commun, 9, 2018
5Y2Z
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Crystal structure of human LGI1 EPTP-ADAM22 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yamagata, A, Fukai, S.
登録日2017-07-27
公開日2018-05-02
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
Nat Commun, 9, 2018
6AVR
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Human alpha-V beta-3 Integrin (intermediate conformation) in complex with the therapeutic antibody LM609
分子名称: Fab LM609 heavy chain, Fab LM609 light chain, Integrin alpha-V, ...
著者Borst, A.J, James, Z.N, Zagotta, W.N, Ginsberg, M, Rey, F.A, DiMaio, F, Backovic, M, Veesler, D.
登録日2017-09-04
公開日2017-11-01
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (35 Å)
主引用文献The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.
Structure, 25, 2017
6AVQ
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The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha-V beta-3 Integrin via Steric Hindrance
分子名称: Integrin alpha-V, Integrin beta-3, LM609 Fab heavy chain, ...
著者Borst, A.J, James, Z.N, Zagotta, W.N, Ginsberg, M, Rey, F.A, DiMaio, F, Backovic, M, Veesler, D.
登録日2017-09-04
公開日2017-11-01
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (35 Å)
主引用文献The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.
Structure, 25, 2017

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