6AVQ

The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha-V beta-3 Integrin via Steric Hindrance

Summary for 6AVQ

• Entry DOI: 10.2210/pdb6avq/pdb
• Related: 5OPY
• EMDB information: 7011 7012 7013
• Descriptor: Integrin alpha-V, Integrin beta-3, LM609 Fab heavy chain, ... (4 entities in total)
• Functional Keywords: alpha-v beta-3 integrin, lm609, vitaxin, abegrin, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 233269.39

Authors

Borst, A.J.,James, Z.N.,Zagotta, W.N.,Ginsberg, M.,Rey, F.A.,DiMaio, F.,Backovic, M.,Veesler, D. (deposition date: 2017-09-04, release date: 2017-11-01, Last modification date: 2024-03-13)

• Primary citation: Borst, A.J.,James, Z.M.,Zagotta, W.N.,Ginsberg, M.,Rey, F.A.,DiMaio, F.,Backovic, M.,Veesler, D.; The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.; Structure, 25:1732-1739.e5, 2017; PubMed: 29033288; DOI: 10.1016/j.str.2017.09.007

Experimental method

ELECTRON MICROSCOPY (35 Å)