6AVQ
The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha-V beta-3 Integrin via Steric Hindrance
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrin alpha-V | polymer | 957 | 105894.2 | 1 | UniProt (P06756) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF20806) | Homo sapiens (Human) | Vitronectin receptor,Vitronectin receptor subunit alpha |
| 2 | B (B) | Integrin beta-3 | polymer | 692 | 76523.1 | 1 | UniProt (P05106) Pfam (PF07974) Pfam (PF07965) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372) | Homo sapiens (Human) | Platelet membrane glycoprotein IIIa,GPIIIa |
| 3 | C (H) | LM609 Fab heavy chain | polymer | 257 | 27223.1 | 1 | Mus musculus | ||
| 4 | D (L) | LM609 Fab light chain | polymer | 214 | 23629.0 | 1 | Mus musculus |
Sequence modifications
A: 1 - 957 (UniProt: P06756)
| PDB | External Database | Details |
|---|---|---|
| Ile 753 | Val 783 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 233269.4 | |
| All* | Total formula weight | 233269.4 |
