3HO5
Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex
Summary for 3HO5
Entry DOI | 10.2210/pdb3ho5/pdb |
Related | 3HO3 3HO4 |
Descriptor | Hedgehog-interacting protein, Sonic hedgehog protein, ZINC ION, ... (4 entities in total) |
Functional Keywords | receptor ectodomain, six-bladed-propeller domain, egf domain, disulfide bond, calcium cation, zinc cation, cell membrane, egf-like domain, glycoprotein, membrane, secreted, autocatalytic cleavage, developmental protein, disease mutation, holoprosencephaly, hydrolase, lipoprotein, microphthalmia, palmitate, protease, signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Peripheral membrane protein (By similarity). Isoform 2: Cytoplasm (Probable): Q96QV1 Sonic hedgehog protein C-product: Secreted, extracellular space (By similarity). Sonic hedgehog protein N-product: Cell membrane; Lipid-anchor (By similarity): Q15465 |
Total number of polymer chains | 3 |
Total formula weight | 127507.95 |
Authors | Hymowitz, S.G.,Bosanac, I. (deposition date: 2009-06-01, release date: 2009-06-23, Last modification date: 2023-09-06) |
Primary citation | Bosanac, I.,Maun, H.R.,Scales, S.J.,Wen, X.,Lingel, A.,Bazan, J.F.,de Sauvage, F.J.,Hymowitz, S.G.,Lazarus, R.A. The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. Nat.Struct.Mol.Biol., 16:691-697, 2009 Cited by PubMed: 19561609DOI: 10.1038/nsmb.1632 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.01 Å) |
Structure validation
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