3HO5
Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN H 400 |
| Chain | Residue |
| B | ASP383 |
| H | HIS140 |
| H | ASP147 |
| H | HIS182 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA H 401 |
| Chain | Residue |
| H | GLU89 |
| H | GLU90 |
| H | ASP95 |
| H | THR125 |
| H | GLU126 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA H 402 |
| Chain | Residue |
| H | GLU90 |
| H | GLU126 |
| H | ASP129 |
| H | ASP131 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ZN A 902 |
| Chain | Residue |
| A | ASP383 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 54 |
| Details | Domain: {"description":"EGF-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 64 |
| Details | Domain: {"description":"EGF-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Region: {"description":"Interaction with SHH zinc binding site"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19561611","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10753901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3M1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1c9u |
| Chain | Residue | Details |
| A | HIS352 | |
| A | ASP371 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1c9u |
| Chain | Residue | Details |
| B | HIS352 | |
| B | ASP371 |
