3HO5

Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0007267	biological_process	cell-cell signaling
H	0007275	biological_process	multicellular organism development

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 400

Chain	Residue
B	ASP383
H	HIS140
H	ASP147
H	HIS182

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA H 401

Chain	Residue
H	GLU89
H	GLU90
H	ASP95
H	THR125
H	GLU126

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA H 402

Chain	Residue
H	GLU90
H	GLU126
H	ASP129
H	ASP131

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN A 902

Chain	Residue
A	ASP383

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Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CcCspGweGDfC

Chain	Residue	Details
A	CYS623-CYS634
A	CYS655-CYS666

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site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CcCspGWegdf....C

Chain	Residue	Details
A	CYS623-CYS634
A	CYS655-CYS666

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:20504762, ECO:0007744|PDB:3MXW

Chain	Residue	Details
H	GLU89
H	GLU90
H	ASP95
H	THR125
H	GLU126
H	ASP129
H	ASP131

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:10753901, ECO:0000269|PubMed:20504762, ECO:0007744|PDB:3M1N, ECO:0007744|PDB:3MXW

Chain	Residue	Details
H	HIS140
H	ASP147
H	HIS182
B	ASN459

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:Q02936

Chain	Residue	Details
H	GLY197
B	ASN447

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site_id	SWS_FT_FI4
Number of Residues	1
Details	LIPID: Cholesterol glycine ester => ECO:0000250|UniProtKB:Q62226

Chain	Residue	Details
H	GLY197

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1c9u

Chain	Residue	Details
A	HIS352
A	ASP371

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1c9u

Chain	Residue	Details
B	HIS352
B	ASP371

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