4MMZ

Integrin AlphaVBeta3 ectodomain bound to an antagonistic tenth domain of Fibronectin

Summary for 4MMZ

Entry DOI	10.2210/pdb4mmz/pdb
Related	1JV2 1L5G 3IJE 4G1E 4G1M 4MMX 4MMY
Descriptor	Integrin alpha-V, GLYCEROL, Integrin beta-3, ... (11 entities in total)
Functional Keywords	integrin, a domain, hybrid domain, psi, egf repeats, beta tail, calf, thigh, beta propeller, rgd motif, fibronectin, vitronectin, cell adhesion
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	198878.71
Authors	van Agthoven, J.,Xiong, J.,Arnaout, M.A. (deposition date: 2013-09-09, release date: 2014-03-26, Last modification date: 2023-09-20)
Primary citation	Van Agthoven, J.F.,Xiong, J.P.,Alonso, J.L.,Rui, X.,Adair, B.D.,Goodman, S.L.,Arnaout, M.A. Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin. Nat.Struct.Mol.Biol., 21:383-388, 2014 Cited by PubMed: 24658351 DOI: 10.1038/nsmb.2797 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation