4MMZ
Integrin AlphaVBeta3 ectodomain bound to an antagonistic tenth domain of Fibronectin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrin alpha-V | polymer | 959 | 106048.4 | 1 | UniProt (P06756) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF20806) | Homo sapiens (human) | Vitronectin receptor,Vitronectin receptor subunit alpha |
| 2 | B (B) | Integrin beta-3 | polymer | 692 | 76523.1 | 1 | UniProt (P05106) Pfam (PF07974) Pfam (PF07965) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372) | Homo sapiens (human) | Platelet membrane glycoprotein IIIa,GPIIIa |
| 3 | C (C) | Fibronectin | polymer | 98 | 10533.8 | 1 | UniProt (P02751) Pfam (PF00041) | Homo sapiens (human) | FN,Cold-insoluble globulin,CIG |
| 4 | D, F, G, H (D, F, G, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E (E) | alpha-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G93290PO) | |||
| 6 | I (I) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 7 | J, K, L, M, N... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 8 | AA, O, P, Q, R... (B, A) | MANGANESE (II) ION | non-polymer | 54.9 | 8 | Chemie (MN) | |||
| 9 | T (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 10 | BA, U (C, A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 11 | CA, DA, EA (A, B, C) | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence modifications
C: 1417 - 1509 (UniProt: P02751)
| PDB | External Database | Details |
|---|---|---|
| Pro 1492 | Gly 1614 | engineered mutation |
| Trp 1496 | Ser 1618 | engineered mutation |
| Asn 1497 | Pro 1619 | engineered mutation |
| Glu 1498 | Ala 1620 | engineered mutation |
| Gly 1499 | Ser 1621 | engineered mutation |
| Gly 1510 | - | expression tag |
| Lys 1511 | - | expression tag |
| Lys 1512 | - | expression tag |
| Gly 1513 | - | expression tag |
| Lys 1514 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 193105.3 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 3357.1 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 2416.3 | |
| All* | Total formula weight | 198878.7 |
