PDB: 153 resultsInfo pagesStatus searchChemie searchBIRD

---

8ITV	KL2.1 in complex with CRM1-Ran-RanBP1 Descriptor: (3~{S},5~{R},6~{E},8~{Z},10~{R},12~{E},14~{E},16~{S})-3,16-bis(azanyl)-8,10,12-trimethyl-16-[(2~{S},4~{R},5~{S},6~{S})-5-methyl-4-oxidanyl-6-[(~{E})-prop-1-enyl]oxan-2-yl]-5-oxidanyl-hexadeca-6,8,12,14-tetraenoic acid, ACETATE ION, CHLORIDE ION, ... Authors: Sun, Q, Jian, L. Deposit date: 2023-03-23 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: KL2.1 in complex with CRM1-Ran-RanBP1 To Be Published
8GCN	CRYO-EM STRUCTURE OF IMPORTIN ALPHA1/BETA HETERODIMER Descriptor: Importin subunit alpha-1, Importin subunit beta-1 Authors: Ko, Y, Cingolani, G. Deposit date: 2023-03-02 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.95 Å) Cite: CRYO-EM STRUCTURE OF IMPORTIN ALPHA1/BETA HETERODIMER To Be Published
8HUF	B28 in complex with CRM1-Ran-RanBP1 Descriptor: 3-[(4-chlorophenyl)carbonylamino]-4-[4-(2,5-dimethylphenyl)piperazin-1-yl]benzoic acid, BROMIDE ION, CHLORIDE ION, ... Authors: Sun, Q, Lei, Y. Deposit date: 2022-12-23 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (2.29 Å) Cite: B28 in complex with CRM1-Ran-RanBP1 To Be Published
8HUG	F1 in complex with CRM1-Ran-RanBP1 Descriptor: 4-[4-(3-chlorophenyl)piperazin-1-yl]-3-[(3-fluorophenyl)sulfonylamino]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... Authors: Sun, Q, Lei, Y. Deposit date: 2022-12-23 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (2.15 Å) Cite: F1 in complex with CRM1-Ran-RanBP1 To Be Published
8HQ4	B27 in complex with CRM1-Ran-RanBP1 Descriptor: 3-[(4-fluorophenyl)carbonylamino]-4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... Authors: Lei, Y, Sun, Q. Deposit date: 2022-12-13 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (2.12 Å) Cite: B27 in complex with CRM1-Ran-RanBP1 To Be Published
8HQ5	G6 in complex with CRM1-Ran-RanBP1 Descriptor: 3-[(4-bromophenyl)carbonylamino]-4-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]benzoic acid, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... Authors: Sun, Q, Lei, Y. Deposit date: 2022-12-13 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (2.25 Å) Cite: F1 in complex with CRM1-Ran-RanBP1 To Be Published
8HQ6	KL2 in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... Authors: Sun, Q, Jian, L. Deposit date: 2022-12-13 Release date: 2023-10-25 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
8HQ3	KL1 in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... Authors: Sun, Q, Jian, L. Deposit date: 2022-12-13 Release date: 2023-10-25 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
8H5B	The cryo-EM structure of nuclear transport receptor Kap114p complex with yeast TATA-box binding protein Descriptor: Importin subunit beta-5, TATA-box-binding protein Authors: Hsia, K.C, Liao, C.C, Wang, C.H, Wu, Y.M. Deposit date: 2022-10-12 Release date: 2023-09-20 Method: ELECTRON MICROSCOPY (4.03 Å) Cite: Structural convergence endows nuclear transport receptor Kap114p with a transcriptional repressor function toward TATA-binding protein. Nat Commun, 14, 2023
7YPZ	Zafirlukast in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... Authors: Sun, Q, Lei, Y. Deposit date: 2022-08-05 Release date: 2023-08-16 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Searching for Novel Noncovalent Nuclear Export Inhibitors through a Drug Repurposing Approach. J.Med.Chem., 66, 2023
8F0X	Cryo-EM structure of Kap114 bound to H2A-H2B Descriptor: Histone H2A.2, Histone H2B.2, Importin subunit beta-5 Authors: Jiou, J, Chook, Y.M. Deposit date: 2022-11-04 Release date: 2023-07-26 Method: ELECTRON MICROSCOPY (3.21 Å) Cite: Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc.Natl.Acad.Sci.USA, 120, 2023
8F19	Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin subunit beta-5, ... Authors: Jiou, J, Chook, Y.M. Deposit date: 2022-11-04 Release date: 2023-07-26 Method: ELECTRON MICROSCOPY (3.49 Å) Cite: Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc.Natl.Acad.Sci.USA, 120, 2023
8F7A	Cryo-EM structure of Importin-9 bound to RanGTP Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-9, ... Authors: Bernardes, N.E, Chook, Y.M. Deposit date: 2022-11-18 Release date: 2023-07-26 Method: ELECTRON MICROSCOPY (3.78 Å) Cite: Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc.Natl.Acad.Sci.USA, 120, 2023
8F1E	Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) and H2A-H2B Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Histone H2A.2, ... Authors: Jiou, J, Chook, Y.M. Deposit date: 2022-11-04 Release date: 2023-07-26 Method: ELECTRON MICROSCOPY (3.28 Å) Cite: Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc.Natl.Acad.Sci.USA, 120, 2023
8SGH	Cryo-EM structure of Karyopherin-beta2 bound to HNRNPH2 PY-NLS Descriptor: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed, Transportin-1 Authors: Gonzalez, A, Fung, H.Y.J, Chook, Y.M. Deposit date: 2023-04-12 Release date: 2023-06-14 Last modified: 2023-08-16 Method: ELECTRON MICROSCOPY (3.17 Å) Cite: A new Karyopherin-beta 2 binding PY-NLS epitope of HNRNPH2 linked to neurodevelopmental disorders. Structure, 31, 2023
7UNK	Structure of Importin-4 bound to the H3-H4-ASF1 histone-histone chaperone complex Descriptor: Histone H3, Histone H4, Histone chaperone, ... Authors: Bernardes, N.E, Chook, Y.M, Fung, H.Y.J, Chen, Z, Li, Y. Deposit date: 2022-04-11 Release date: 2022-09-21 Last modified: 2022-10-05 Method: ELECTRON MICROSCOPY (3.45 Å) Cite: Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex. Proc.Natl.Acad.Sci.USA, 119, 2022
8DYO	Cryo-EM structure of Importin-4 bound to RanGTP Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-4, ... Authors: Bernardes, N.E, Fung, H.Y.J, Li, Y, Chen, Z, Chook, Y.M. Deposit date: 2022-08-04 Release date: 2022-09-21 Last modified: 2022-10-05 Method: ELECTRON MICROSCOPY (7.1 Å) Cite: Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex. Proc.Natl.Acad.Sci.USA, 119, 2022
7VPW	Crystal structure of Transportin-1 in complex with BAP1 PY-NLS (residues 706-724) Descriptor: BRCA1-associated protein 1 (BAP1), Transportin-1 Authors: Yang, T.J, Hsu, S.T.D. Deposit date: 2021-10-18 Release date: 2022-04-20 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.76 Å) Cite: Tumor suppressor BAP1 nuclear import is governed by transportin-1. J.Cell Biol., 221, 2022
7DBG	Yeast CRM1e (apo) in complex with Ran-RanBP1 Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, CRM1 isoform 1, ... Authors: Sun, Q, Lei, Y. Deposit date: 2020-10-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin. J.Nat.Prod., 84, 2021
6LQ9	S109 in complex with CRM1-Ran-RanBP1 Descriptor: (3~{R},4~{S})-1-[[6-chloranyl-5-(trifluoromethyl)pyridin-2-yl]amino]-3,4-dimethyl-pyrrolidine-2,5-dione, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Lei, Y. Deposit date: 2020-01-13 Release date: 2021-06-23 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure-Guided Design of the First Noncovalent Small-Molecule Inhibitor of CRM1. J.Med.Chem., 64, 2021
7CND	NCI-1 in complex with CRM1-Ran-RanBP1 Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, CRM1 isoform 1, ... Authors: Sun, Q, Lei, Y. Deposit date: 2020-07-31 Release date: 2021-06-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure-Guided Design of the First Noncovalent Small-Molecule Inhibitor of CRM1. J.Med.Chem., 64, 2021
6M60	Plumbagin in complex with CRM1#-Ran-RanBP1 Descriptor: (2~{R})-2-methyl-5-oxidanyl-2,3-dihydronaphthalene-1,4-dione, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Sun, Q, Lei, Y. Deposit date: 2020-03-12 Release date: 2021-06-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin. J.Nat.Prod., 84, 2021
6M6X	Oridonin in complex with CRM1#-Ran-RanBP1 Descriptor: (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one, 1,2-ETHANEDIOL, CHLORIDE ION, ... Authors: Sun, Q, Lei, Y. Deposit date: 2020-03-16 Release date: 2021-03-17 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.88 Å) Cite: Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin. J.Nat.Prod., 84, 2021
7B51	Crystal structure of human CRM1 covalently modified by 2-mercaptoethanol at Cys528 Descriptor: BETA-MERCAPTOETHANOL, Exportin-1, GTP-binding nuclear protein Ran, ... Authors: Shaikhqasem, A, Ficner, R. Deposit date: 2020-12-03 Release date: 2021-03-10 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.58 Å) Cite: Crystal structure of human CRM1, covalently modified by 2-mercaptoethanol on Cys528, in complex with RanGTP. Acta Crystallogr.,Sect.F, 77, 2021
7CYL	Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L) Descriptor: RNA-binding protein FUS, Transportin-1 Authors: Yoshizawa, T, Chook, Y.M. Deposit date: 2020-09-03 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Mechanism of karyopherin-beta 2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X). Sci Rep, 11, 2021

 

1234567>