6M6X
Oridonin in complex with CRM1#-Ran-RanBP1
Summary for 6M6X
Entry DOI | 10.2210/pdb6m6x/pdb |
Related | 5YSU 6M60 |
Descriptor | GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (9 entities in total) |
Functional Keywords | active ran, complex, transport protein, inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 157780.96 |
Authors | |
Primary citation | Lei, Y.,Li, Y.,Tan, Y.,Qian, Z.,Zhou, Q.,Jia, D.,Sun, Q. Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin. J.Nat.Prod., 84:1478-1488, 2021 Cited by PubMed: 33890470DOI: 10.1021/acs.jnatprod.0c01231 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.88 Å) |
Structure validation
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