6LQ9

S109 in complex with CRM1-Ran-RanBP1

Summary for 6LQ9

• Entry DOI: 10.2210/pdb6lq9/pdb
• Descriptor: GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (10 entities in total)
• Functional Keywords: transport protein, nuclear export, complex, mutant, activation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 161767.70

Authors

Sun, Q.,Lei, Y. (deposition date: 2020-01-13, release date: 2021-06-23, Last modification date: 2024-03-20)

• Primary citation: Lei, Y.,An, Q.,Shen, X.F.,Sui, M.,Li, C.,Jia, D.,Luo, Y.,Sun, Q.; Structure-Guided Design of the First Noncovalent Small-Molecule Inhibitor of CRM1.; J.Med.Chem., 64:6596-6607, 2021; PubMed: 33974430; DOI: 10.1021/acs.jmedchem.0c01675

Experimental method

X-RAY DIFFRACTION (2.5 Å)