8SGH

Cryo-EM structure of Karyopherin-beta2 bound to HNRNPH2 PY-NLS

Summary for 8SGH

Entry DOI	10.2210/pdb8sgh/pdb
EMDB information	40455
Descriptor	Transportin-1, Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed (2 entities in total)
Functional Keywords	rna-binding protein tnpo1 cryo-em kapb2 hnrnp, transport protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	115732.62
Authors	Gonzalez, A.,Fung, H.Y.J.,Chook, Y.M. (deposition date: 2023-04-12, release date: 2023-06-14, Last modification date: 2023-08-16)
Primary citation	Gonzalez, A.,Kim, H.J.,Freibaum, B.D.,Fung, H.Y.J.,Brautigam, C.A.,Taylor, J.P.,Chook, Y.M. A new Karyopherin-beta 2 binding PY-NLS epitope of HNRNPH2 linked to neurodevelopmental disorders. Structure, 31:924-934.e4, 2023 Cited by PubMed: 37279758 DOI: 10.1016/j.str.2023.05.010 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.17 Å)

Structure validation