PDB: 103 件ウェブページステータス検索Chemie searchBIRD

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5GQ9	Crystal structure of Thermus thermophilus Argonaute in complex with g1C siDNA and DNA target 分子名称: DNA (5'-D(P*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(P*CP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), MAGNESIUM ION, ... 著者 Zhao, H, Sheng, G, Wang, Y. 登録日 2016-08-06 公開日 2017-08-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of Thermus thermophilus Argonaute in complex with g1C siDNA and DNA target To Be Published
4Z4G	Human Argonaute2 Bound to t1-Inosine Target RNA 分子名称: MAGNESIUM ION, PHENOL, Protein argonaute-2, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2015-04-02 公開日 2015-09-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets. Elife, 4, 2015
1Z25	Structure of P.furiosus Argonaute with bound Mn2+ 分子名称: Argonaute, MANGANESE (II) ION 著者 Rivas, F.V, Tolia, N.H, Song, J.J, Aragon, J.P, Liu, J, Hannon, G.J, Joshua-Tor, L. 登録日 2005-03-07 公開日 2005-04-05 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Purified Argonaute2 and an siRNA form recombinant human RISC. Nat.Struct.Mol.Biol., 12, 2005
5XPG	Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 6'U7' on the target strand 分子名称: 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*A P*GP*T)-3', 5'-R(*UP*AP*U*AP*CP*AP*AP*CP*CP*UP*AP*CP*AP*UP*AP*CP*CP*UP*CP* G)-3', MAGNESIUM ION, ... 著者 Sheng, G, Gogakos, T, Wang, J, Zhao, H, Serganov, A, Juranek, S, Tuschl, T, Patel, J.D, Wang, Y. 登録日 2017-06-02 公開日 2018-04-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes. Nucleic Acids Res., 45, 2017
4Z4F	Human Argonaute2 Bound to t1-DAP Target RNA 分子名称: MAGNESIUM ION, PHENOL, Protein argonaute-2, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2015-04-02 公開日 2015-09-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets. Elife, 4, 2015
3HK2	Crystal structure of T. thermophilus Argonaute N478 mutant protein complexed with DNA guide strand and 19-nt RNA target strand 分子名称: 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ... 著者 Wang, Y, Li, H, Sheng, G, Patel, D.J. 登録日 2009-05-22 公開日 2009-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature, 461, 2009
4Z4I	Human Argonaute2 A481T Mutant Bound to t1-G Target RNA 分子名称: MAGNESIUM ION, PHENOL, Protein argonaute-2, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2015-04-02 公開日 2015-09-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.801 Å) 主引用文献 Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets. Elife, 4, 2015
8PVV	Archaeoglobus fulgidus AfAgo complex with AfAgo-N protein (fAfAgo) bound with 30 nt RNA guide and 51 nt DNA target 分子名称: Archaeoglobus fulgidus AfAgo-N protein, DNA (51-MER), MAGNESIUM ION, ... 著者 Manakova, E.N, Zaremba, M, Pocevicuite, R, Golovinas, E, Sasnauskas, G, Zagorskaite, E, Silanskas, A. 登録日 2023-07-18 公開日 2024-01-24 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.81 Å) 主引用文献 The missing part: the Archaeoglobus fulgidus Argonaute forms a functional heterodimer with an N-L1-L2 domain protein. Nucleic Acids Res., 52, 2024
4N47	Structure of Thermus thermophilus Argonaute bound to guide DNA and 12-mer target DNA 分子名称: 5'-D(*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', Argonaute, ... 著者 Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y. 登録日 2013-10-08 公開日 2014-01-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.823 Å) 主引用文献 Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc.Natl.Acad.Sci.USA, 111, 2014
5W6V	The Structure of human Argonaute-1 in complex with the hook motif of human GW182 分子名称: Protein argonaute-1, RNA (5'-R(P*AP*AP*UP*AP*UP*UP*AP*AP*AP*A)-3'), Trinucleotide repeat-containing gene 6A protein 著者 Elkayam, E, Faehnle, C.R, Joshua-Tor, L. 登録日 2017-06-17 公開日 2017-07-26 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.828 Å) 主引用文献 Multivalent Recruitment of Human Argonaute by GW182. Mol. Cell, 67, 2017
5G5T	Structure of the Argonaute protein from Methanocaldcoccus janaschii in complex with guide DNA 分子名称: ARGONAUTE, GUIDE DNA, MAGNESIUM ION, ... 著者 Schneider, S, Oellig, C.A, Keegan, R, Grohmann, D, Zander, A, Willkomm, S. 登録日 2016-06-03 公開日 2017-02-08 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein. Nat Microbiol, 2, 2017
4N76	Structure of Thermus thermophilus Argonaute bound to guide DNA and cleaved target DNA with Mn2+ 分子名称: 5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', Argonaute, ... 著者 Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y. 登録日 2013-10-15 公開日 2014-01-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc.Natl.Acad.Sci.USA, 111, 2014
4OLB	Crystal Structure of Human Argonaute2 Bound to Tryptophan 分子名称: 5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*U)-3', Protein argonaute-2, TRYPTOPHAN 著者 Schirle, N.T, MacRae, I.J. 登録日 2014-01-23 公開日 2014-02-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.899 Å) 主引用文献 The crystal structure of human Argonaute2. Science, 336, 2012
6N4O	Human Argonaute2-miR-122 bound to a seed and supplementary paired target 分子名称: Protein argonaute-2, RNA (5'-R(*CP*CP*AP*UP*UP*GP*UP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3'), RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') 著者 Sheu-Gruttadauria, J, MacRae, I.J. 登録日 2018-11-19 公開日 2019-05-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.899 Å) 主引用文献 Beyond the seed: structural basis for supplementary microRNA targeting by human Argonaute2. Embo J., 38, 2019
8JPX	Cryo-EM structure of PfAgo-guide DNA-target DNA complex 分子名称: Excess DNA, Guide DNA, MAGNESIUM ION, ... 著者 Zhuang, L. 登録日 2023-06-13 公開日 2024-01-31 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute. Mol.Cell, 84, 2024
8WD8	Cryo-EM structure of TtdAgo-guide DNA-target DNA complex 分子名称: Argonaute family protein, Guide DNA, MAGNESIUM ION, ... 著者 Zhuang, L. 登録日 2023-09-14 公開日 2024-01-31 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute. Mol.Cell, 84, 2024
6KR6	Crystal structure of Drosophila Piwi 分子名称: MERCURY (II) ION, Protein piwi, ZINC ION, ... 著者 Yamaguchi, S, Oe, A, Yamashita, K, Hirano, S, Mastumoto, N, Ishitani, R, Nishimasu, H, Nureki, O. 登録日 2019-08-21 公開日 2020-02-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of Drosophila Piwi. Nat Commun, 11, 2020
4W5N	The Crystal Structure of Human Argonaute2 Bound to a Defined Guide RNA 分子名称: MAGNESIUM ION, PHENOL, Protein argonaute-2, ... 著者 Schirle, N.T, Sheu-Gruttadauria, J, MacRae, I.J. 登録日 2014-08-18 公開日 2014-11-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Gene regulation. Structural basis for microRNA targeting. Science, 346, 2014
5XPA	Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 9'U10' on the target strand 分子名称: DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), MAGNESIUM ION, RNA (5'-R(P*AP*UP*AP*CP*AP*AP*CP*CP*GP*UP*UP*CP*UP*AP*CP*UP*CP*CP*G)-3'), ... 著者 Sheng, G, Gogakos, T, Wang, J, Zhao, H, Serganov, A, Juranek, S, Tuschl, T, Patel, J.D, Wang, Y. 登録日 2017-06-01 公開日 2018-04-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes. Nucleic Acids Res., 45, 2017
1YVU	Crystal structure of A. aeolicus Argonaute 分子名称: CALCIUM ION, hypothetical protein aq_1447 著者 Yuan, Y.R, Pei, Y, Ma, J.B, Kuryavyi, V, Zhadina, M, Meister, G, Chen, H.Y, Dauter, Z, Tuschl, T, Patel, D.J. 登録日 2005-02-16 公開日 2005-08-09 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of A. aeolicus Argonaute provides unique perspectives into the mechanism of guide strand-mediated mRNA cleavage Mol.Cell, 19, 2005
5XOW	Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 6'A7' on the target strand 分子名称: DNA (5'-D(P*(TD)P*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), MAGNESIUM ION, RNA (5'-R(P*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*AP*CP*CP*UP*CP*G)-3'), ... 著者 Sheng, G, Wang, J, Zhao, H, Wang, Y. 登録日 2017-05-31 公開日 2017-10-04 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.902 Å) 主引用文献 Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes Nucleic Acids Res., 45, 2017
5JS2	Human Argonaute-2 Bound to a Modified siRNA 分子名称: MAGNESIUM ION, PHENOL, PHOSPHATE ION, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2016-05-07 公開日 2016-07-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.954 Å) 主引用文献 Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide. J.Am.Chem.Soc., 138, 2016
7YGN	Cryo-EM structure of the Mili in complex with piRNA 分子名称: MAGNESIUM ION, Piwi-like protein 2, piRNA 著者 Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. 登録日 2022-07-11 公開日 2024-01-24 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing. Nat.Struct.Mol.Biol., 2024
3DLH	Crystal structure of the guide-strand-containing Argonaute protein silencing complex 分子名称: ACETIC ACID, Argonaute, DNA (5'-D(DTP*DGP*DAP*DGP*DGP*DTP*DAP*DGP*DTP*DAP*DGP*DGP*DTP*DTP*DGP*DTP*DAP*DTP*DAP*DGP*DT)-3'), ... 著者 Wang, Y, Sheng, G, Patel, D.J. 登録日 2008-06-27 公開日 2008-09-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of the guide-strand-containing argonaute silencing complex. Nature, 456, 2008
7KI3	Human Argonaute2:miR-122 bound to the HCV genotype 1a site-1 RNA 分子名称: BARIUM ION, HCV genotype 1a miR-122 site-1, Protein argonaute-2, ... 著者 Gebert, L.F.R, MacRae, I.J. 登録日 2020-10-22 公開日 2021-10-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A structured RNA motif locks Argonaute2:miR-122 onto the 5' end of the HCV genome. Nat Commun, 12, 2021

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