5JS2

Human Argonaute-2 Bound to a Modified siRNA

Summary for 5JS2

Related5JS1
DescriptorProtein argonaute-2, modified siRNA, PHENOL, ... (6 entities in total)
Functional Keywordsargonaute, sirna, rnai, nuclease, hydrolase-rna complex, hydrolase/rna
Biological sourceHomo sapiens (Human)
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Cellular locationCytoplasm, P-body Q9UKV8
Total number of polymer chains2
Total molecular weight99650.11
Authors
Schirle, N.T.,MacRae, I.J. (deposition date: 2016-05-07, release date: 2016-07-20, Last modification date: 2016-08-10)
Primary citation
Schirle, N.T.,Kinberger, G.A.,Murray, H.F.,Lima, W.F.,Prakash, T.P.,MacRae, I.J.
Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide.
J.Am.Chem.Soc., 138:8694-8697, 2016
PubMed: 27380263 (PDB entries with the same primary citation)
DOI: 10.1021/jacs.6b04454
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.954 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.258800.7%4.8%0.00MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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