6N4O
Human Argonaute2-miR-122 bound to a seed and supplementary paired target
Summary for 6N4O
Entry DOI | 10.2210/pdb6n4o/pdb |
Descriptor | Protein argonaute-2, RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3'), RNA (5'-R(*CP*CP*AP*UP*UP*GP*UP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3') (3 entities in total) |
Functional Keywords | rna-binding protein, microrna, target directed microrna decay, hydrolase-rna complex, rna binding protein, rna binding protein-rna complex, rna binding protein/rna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 109782.63 |
Authors | Sheu-Gruttadauria, J.,MacRae, I.J. (deposition date: 2018-11-19, release date: 2019-05-08, Last modification date: 2023-10-11) |
Primary citation | Sheu-Gruttadauria, J.,Xiao, Y.,Gebert, L.F.,MacRae, I.J. Beyond the seed: structural basis for supplementary microRNA targeting by human Argonaute2. Embo J., 38:e101153-e101153, 2019 Cited by PubMed: 31268608DOI: 10.15252/embj.2018101153 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.899 Å) |
Structure validation
Download full validation report