7E8D
| NSD2 E1099K mutant bound to nucleosome | 分子名称: | DNA (185-MER), Histone H2A type 1, Histone H2B type 1-J, ... | 著者 | Sengoku, T, Sato, K, Nishizawa, T, Nureki, O, Ogata, K. | 登録日 | 2021-03-01 | 公開日 | 2021-11-10 | 最終更新日 | 2022-02-02 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2. Nat Commun, 12, 2021
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7LMS
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7BJ1
| Crystal structure of SMYD3 with diperodon S enantiomer bound to allosteric site | 分子名称: | ACETATE ION, Diperodon (S-enantiomer), GLYCEROL, ... | 著者 | Talibov, V.O, Cederfelt, D, Dobritzsch, D, Danielson, U.H. | 登録日 | 2021-01-13 | 公開日 | 2021-03-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase Chembiochem, 22, 2021
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7KSR
| PRC2:EZH1_A from a dimeric PRC2 bound to a nucleosome | 分子名称: | Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... | 著者 | Grau, D.J, Armache, K.J. | 登録日 | 2020-11-24 | 公開日 | 2021-02-03 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. Nat Commun, 12, 2021
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7KTP
| PRC2:EZH1_B from a dimeric PRC2 bound to a nucleosome | 分子名称: | Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... | 著者 | Grau, D.J, Armache, K.J. | 登録日 | 2020-11-24 | 公開日 | 2021-02-03 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. Nat Commun, 12, 2021
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7KSO
| Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2 | 分子名称: | Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... | 著者 | Grau, D.J, Armache, K.J. | 登録日 | 2020-11-23 | 公開日 | 2021-02-03 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. Nat Commun, 12, 2021
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7AT8
| Histone H3 recognition by nucleosome-bound PRC2 subunit EZH2. | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3.2, ... | 著者 | Finogenova, K, Benda, C, Schaefer, I.B, Poepsel, S, Strauss, M, Mueller, J. | 登録日 | 2020-10-29 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3. Elife, 9, 2020
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7DCF
| Crystal structure of EHMT2 SET domain in complex with compound 10 | 分子名称: | 5'-methoxy-6'-(1-methyl-2,3,4,7-tetrahydroazepin-5-yl)spiro[cyclobutane-1,3'-indole]-2'-amine, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYLMETHIONINE, ... | 著者 | Suzuki, M, Katayama, K. | 登録日 | 2020-10-26 | 公開日 | 2021-02-10 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating beta-Thalassemia and Sickle Cell Disease. Acs Med.Chem.Lett., 12, 2021
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7D20
| Cryo-EM structure of SET8-CENP-A-nucleosome complex | 分子名称: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | 著者 | Ho, C.-H, Takizawa, Y, Kobayashi, W, Arimura, Y, Kurumizaka, H. | 登録日 | 2020-09-15 | 公開日 | 2021-02-10 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase. Life Sci Alliance, 4, 2021
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7D1Z
| Cryo-EM structure of SET8-nucleosome complex | 分子名称: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | 著者 | Ho, C.-H, Takizawa, Y, Kobayashi, W, Arimura, Y, Kurumizaka, H. | 登録日 | 2020-09-15 | 公開日 | 2021-02-10 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase. Life Sci Alliance, 4, 2021
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7CRQ
| NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (2:1 binding mode) | 分子名称: | DNA (168-MER), Histone H2A, Histone H2B, ... | 著者 | Li, W, Tian, W, Yuan, G, Deng, P, Gozani, O, Patel, D, Wang, Z. | 登録日 | 2020-08-14 | 公開日 | 2020-10-21 | 最終更新日 | 2021-03-03 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. Nature, 590, 2021
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7CRP
| NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (1:1 binding mode) | 分子名称: | DNA (168-MER), Histone H2A, Histone H2B, ... | 著者 | Li, W, Tian, W, Yuan, G, Deng, P, Gozani, O, Patel, D, Wang, Z. | 登録日 | 2020-08-14 | 公開日 | 2020-10-21 | 最終更新日 | 2021-03-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. Nature, 590, 2021
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7CRO
| NSD2 bearing E1099K/T1150A dual mutation in complex with 187-bp NCP | 分子名称: | DNA (168-MER), Histone H2A, Histone H2B, ... | 著者 | Li, W, Tian, W, Yuan, G, Deng, P, Gozani, O, Patel, D, Wang, Z. | 登録日 | 2020-08-14 | 公開日 | 2020-10-21 | 最終更新日 | 2021-03-03 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. Nature, 590, 2021
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7CRR
| Native NSD3 bound to 187-bp nucleosome | 分子名称: | DNA (168-MER), DNA(168-MER), Histone H2A, ... | 著者 | Li, W, Tian, W, Yuan, G, Deng, P, Gozani, O, Patel, D, Wang, Z. | 登録日 | 2020-08-14 | 公開日 | 2020-10-21 | 最終更新日 | 2021-03-03 | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | 主引用文献 | Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. Nature, 590, 2021
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6ZRB
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6X0P
| Ash1L SET domain Q2265A mutant in complex with AS-5 | 分子名称: | 3-[6-(aminomethyl)-1-(2-hydroxyethyl)-1H-indol-3-yl]benzene-1-carbothioamide, Histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ... | 著者 | Rogawski, D.S, Li, H, Borkin, D, Cierpicki, T, Grembecka, J. | 登録日 | 2020-05-17 | 公開日 | 2021-04-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun, 12, 2021
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6Z2A
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6WZW
| Ash1L SET domain in complex with AS-85 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Histone-lysine N-methyltransferase ASH1L, N-{[3-(3-carbamothioylphenyl)-1-{1-[(trifluoromethyl)sulfonyl]piperidin-4-yl}-1H-indol-6-yl]methyl}azetidine-3-carboxamide, ... | 著者 | Li, H, Deng, J, Cierpicki, T, Grembecka, J. | 登録日 | 2020-05-14 | 公開日 | 2021-04-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun, 12, 2021
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6YUH
| Crystal structure of SMYD3 with diperodon R enantiomer bound to allosteric site | 分子名称: | Diperodon, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... | 著者 | Cederfelt, D, Talibov, V.O, Dobritzsch, D, Danielson, U.H. | 登録日 | 2020-04-27 | 公開日 | 2021-01-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase. Chembiochem, 22, 2021
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6WKR
| PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome | 分子名称: | DNA (314-MER), Histone H2A type 1, Histone H2B 1.1, ... | 著者 | Kasinath, V, Nogales, E, Beck, C, Sauer, P, Poepsel, S, Kosmatka, J, Faini, M, Toso, D, Aebersold, R. | 登録日 | 2020-04-16 | 公開日 | 2021-02-03 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science, 371, 2021
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6WK2
| SETD3 mutant (N255V) in Complex with an Actin Peptide with His73 Replaced with Methionine | 分子名称: | 1,2-ETHANEDIOL, Actin, cytoplasmic 2, ... | 著者 | Dai, S, Horton, J.R, Cheng, X. | 登録日 | 2020-04-15 | 公開日 | 2020-06-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Characterization of SETD3 methyltransferase-mediated protein methionine methylation. J.Biol.Chem., 295, 2020
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6WK1
| SETD3 in Complex with an Actin Peptide with His73 Replaced with Methionine | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Actin, ... | 著者 | Dai, S, Horton, J.R, Cheng, X. | 登録日 | 2020-04-15 | 公開日 | 2020-06-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Characterization of SETD3 methyltransferase-mediated protein methionine methylation. J.Biol.Chem., 295, 2020
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7BUC
| Crystal structure of EHMT2 SET domain in complex with compound 13 | 分子名称: | Histone-lysine N-methyltransferase EHMT2, N2-[4-methoxy-3-(2,3,4,7-tetrahydro-1H-azepin-5-yl)phenyl]-N4,6-dimethyl-pyrimidine-2,4-diamine, S-ADENOSYLMETHIONINE, ... | 著者 | Suzuki, M, Mizuno, M, Katayama, K. | 登録日 | 2020-04-06 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines. Bioorg.Med.Chem.Lett., 30, 2020
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7BTV
| Crystal structure of EHMT2 SET domain in complex with compound 5. | 分子名称: | Histone-lysine N-methyltransferase EHMT2, N~2~-{4-methoxy-3-[3-(pyrrolidin-1-yl)propoxy]phenyl}-N~4~,6-dimethylpyrimidine-2,4-diamine, S-ADENOSYLMETHIONINE, ... | 著者 | Suzuki, M, Mizuno, T, Katayama, K. | 登録日 | 2020-04-03 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines. Bioorg.Med.Chem.Lett., 30, 2020
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7BRE
| The crystal structure of MLL2 in complex with ASH2L and RBBP5 | 分子名称: | Histone-lysine N-methyltransferase 2B, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Li, Y, Zhao, L, Chen, Y. | 登録日 | 2020-03-28 | 公開日 | 2020-07-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.803 Å) | 主引用文献 | Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases. Structure, 28, 2020
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