7E8D

NSD2 E1099K mutant bound to nucleosome

Summary for 7E8D

• Entry DOI: 10.2210/pdb7e8d/pdb
• EMDB information: 31015
• Descriptor: Histone H3.1, Histone H4, Histone H2A type 1, ... (9 entities in total)
• Functional Keywords: chromatin, epigenetics, histone methyltransferase, muitiple myeloma, gene regulation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 11
• Total formula weight: 252528.67

Authors

Sengoku, T.,Sato, K.,Nishizawa, T.,Nureki, O.,Ogata, K. (deposition date: 2021-03-01, release date: 2021-11-10, Last modification date: 2022-02-02)

• Primary citation: Sato, K.,Kumar, A.,Hamada, K.,Okada, C.,Oguni, A.,Machiyama, A.,Sakuraba, S.,Nishizawa, T.,Nureki, O.,Kono, H.,Ogata, K.,Sengoku, T.; Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2.; Nat Commun, 12:6605-6605, 2021; PubMed: 34782608; DOI: 10.1038/s41467-021-26913-5

Experimental method

ELECTRON MICROSCOPY (2.8 Å)