7E8D
NSD2 E1099K mutant bound to nucleosome
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, E | Histone H3.1 | polymer | 135 | 15308.0 | 2 | UniProt (P68431) Pfam (PF00125) In PDB | Homo sapiens (Human) | Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l |
2 | B, F | Histone H4 | polymer | 102 | 11263.2 | 2 | UniProt (P62805) Pfam (PF15511) In PDB | Homo sapiens (Human) | |
3 | C, G | Histone H2A type 1 | polymer | 129 | 13990.3 | 2 | UniProt (P0C0S8) Pfam (PF00125) Pfam (PF16211) In PDB | Homo sapiens (Human) | H2A.1,Histone H2A/ptl |
4 | D, H | Histone H2B type 1-J | polymer | 125 | 13804.0 | 2 | UniProt (P06899) Pfam (PF00125) In PDB | Homo sapiens (Human) | Histone H2B.1,Histone H2B.r,H2B/r |
5 | I | DNA (185-MER) | polymer | 185 | 56841.2 | 1 | synthetic construct | ||
6 | J | DNA (185-MER) | polymer | 185 | 57392.5 | 1 | synthetic construct | ||
7 | K | Histone-lysine N-methyltransferase NSD2 | polymer | 254 | 28986.1 | 1 | UniProt (O96028) Pfam (PF17907) Pfam (PF00856) In PDB | Homo sapiens (Human) | Multiple myeloma SET domain-containing protein,MMSET,Nuclear SET domain-containing protein 2,Protein trithorax-5,Wolf-Hirschhorn syndrome candidate 1 protein |
8 | K | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
9 | K | SINEFUNGIN | non-polymer | 381.4 | 1 | Chemie (SFG) |
Sequence modifications
A, E: 1 - 135 (UniProt: P68431)
K: 973 - 1226 (UniProt: O96028)
PDB | External Database | Details |
---|---|---|
Met 36 | Lys 37 | variant |
PDB | External Database | Details |
---|---|---|
Lys 1099 | Glu 1099 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 11 |
Total formula weight | 251951.1 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 577.6 | |
All* | Total formula weight | 252528.7 |