7AT8

Histone H3 recognition by nucleosome-bound PRC2 subunit EZH2.

Summary for 7AT8

Entry DOI	10.2210/pdb7at8/pdb
EMDB information	11910
Descriptor	Isoform 2 of Histone-lysine N-methyltransferase EZH2,Isoform 2 of Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Isoform 2 of Histone-lysine N-methyltransferase EZH2,Isoform 2 of Histone-lysine N-methyltransferase EZH2, S-ADENOSYL-L-HOMOCYSTEINE, Polycomb protein SUZ12, ... (10 entities in total)
Functional Keywords	polycomb, nucleosome, histone methyltransferase, prc2, ezh2, h3k36, h3 tail, gene regulation, h3, histone h3, polycomb repressive complex 2, cryo-em, nucleosome recognition, h3k36me2, h3k36me3
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	375667.22
Authors	Finogenova, K.,Benda, C.,Schaefer, I.B.,Poepsel, S.,Strauss, M.,Mueller, J. (deposition date: 2020-10-29, release date: 2020-12-09)
Primary citation	Finogenova, K.,Bonnet, J.,Poepsel, S.,Schafer, I.B.,Finkl, K.,Schmid, K.,Litz, C.,Strauss, M.,Benda, C.,Muller, J. Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3. Elife, 9:-, 2020 Cited by PubMed: 33211010 DOI: 10.7554/eLife.61964 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.4 Å)

Structure validation