7AT8
Histone H3 recognition by nucleosome-bound PRC2 subunit EZH2.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 2 of Histone-lysine N-methyltransferase EZH2,Isoform 2 of Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Isoform 2 of Histone-lysine N-methyltransferase EZH2,Isoform 2 of Histone-lysine N-methyltransferase EZH2 | polymer | 764 | 87195.3 | 1 | UniProt (Q15910-2) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856) UniProt (by SIFTS) (Q15910) | Homo sapiens (Human) | ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6,ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6 |
| 2 | B (C) | Polycomb protein SUZ12 | polymer | 739 | 83181.9 | 1 | UniProt (Q15022) Pfam (PF23320) Pfam (PF09733) | Homo sapiens (Human) | Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog |
| 3 | C, G (D, H) | Histone H3.2 | polymer | 135 | 15303.9 | 2 | UniProt (P84233) Pfam (PF00125) | Xenopus laevis (African clawed frog) | |
| 4 | D, H (E, I) | Histone H4 | polymer | 102 | 11263.2 | 2 | UniProt (P62799) Pfam (PF15511) | Xenopus laevis (African clawed frog) | |
| 5 | E, I (F, J) | Histone H2A | polymer | 129 | 13978.2 | 2 | UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211) UniProt (by SIFTS) (P06897) | Xenopus laevis (African clawed frog) | |
| 6 | F, J (G, K) | Histone H2B 1.1 | polymer | 122 | 13524.8 | 2 | UniProt (P02281) Pfam (PF00125) | Xenopus laevis (African clawed frog) | H2B1.1 |
| 7 | K (T) | Widom601 DNA plus linker | polymer | 156 | 47904.5 | 1 | synthetic construct | ||
| 8 | L (U) | Widom601 DNA plus linker | polymer | 156 | 48402.9 | 1 | synthetic construct | ||
| 9 | M, N, O, P, Q... (A) | ZINC ION | non-polymer | 65.4 | 7 | Chemie (ZN) | |||
| 10 | T (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) |
Sequence modifications
A: 1 - 491 (UniProt: Q15910-2)
A: 492 - 504 (PDB: 7AT8)
A: 505 - 764 (UniProt: Q15910-2)
D, H: 1 - 135 (UniProt: P84233)
G, K: 1 - 122 (UniProt: P02281)
| PDB | External Database | Details |
|---|---|---|
| Pro | Arg 298 | conflict |
A: 505 - 764 (UniProt: Q15910-2)
D, H: 1 - 135 (UniProt: P84233)
| PDB | External Database | Details |
|---|---|---|
| Ala 102 | Gly 103 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Thr 29 | Ser 33 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 374824.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 842.3 | |
| All* | Total formula weight | 375667.2 |
