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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7AT8

Histone H3 recognition by nucleosome-bound PRC2 subunit EZH2.

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AIsoform 2 of Histone-lysine N-methyltransferase EZH2,Isoform 2 of Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Isoform 2 of Histone-lysine N-methyltransferase EZH2,Isoform 2 of Histone-lysine N-methyltransferase EZH2polymer76487195.31UniProt (Q15910-2)
Pfam (PF11616)
Pfam (PF18118)
Pfam (PF21358)
Pfam (PF18264)
Pfam (PF00856)
UniProt (by SIFTS) (Q15910)
In PDB		Homo sapiens (Human)ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6,ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6
2CPolycomb protein SUZ12polymer73983181.91UniProt (Q15022)
Pfam (PF09733)
In PDB		Homo sapiens (Human)Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog
3D, HHistone H3.2polymer13515303.92UniProt (P84233)
Pfam (PF00125)
In PDB		Xenopus laevis (African clawed frog)
4E, IHistone H4polymer10211263.22UniProt (P62799)
Pfam (PF15511)
In PDB		Xenopus laevis (African clawed frog)
5F, JHistone H2Apolymer12913978.22UniProt (Q6AZJ8)
Pfam (PF16211)
Pfam (PF00125)
UniProt (by SIFTS) (P06897)
In PDB		Xenopus laevis (African clawed frog)
6G, KHistone H2B 1.1polymer12213524.82UniProt (P02281)
Pfam (PF00125)
In PDB		Xenopus laevis (African clawed frog)H2B1.1
7TWidom601 DNA plus linkerpolymer15647904.51synthetic construct
8UWidom601 DNA plus linkerpolymer15648402.91synthetic construct
9AZINC IONnon-polymer65.47Chemie (ZN)
10AS-ADENOSYL-L-HOMOCYSTEINEnon-polymer384.41Chemie (SAH)
Sequence modifications
A: 1 - 491 (UniProt: Q15910-2)
PDBExternal DatabaseDetails
ProArg 298conflict
A: 492 - 504 (PDB: 7AT8)
A: 505 - 764 (UniProt: Q15910-2)
D, H: 1 - 135 (UniProt: P84233)
PDBExternal DatabaseDetails
Ala 102Gly 103conflict
G, K: 1 - 122 (UniProt: P02281)
PDBExternal DatabaseDetails
Thr 29Ser 33conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains12
Total formula weight374824.9
Non-Polymers*Number of molecules8
Total formula weight842.3
All*Total formula weight375667.2
*Water molecules are not included.

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PDB entries from 2024-07-17

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