6YUH

Crystal structure of SMYD3 with diperodon R enantiomer bound to allosteric site

Summary for 6YUH

• Entry DOI: 10.2210/pdb6yuh/pdb
• Descriptor: Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, GLYCEROL, ... (6 entities in total)
• Functional Keywords: methyltransferase, complex, inhibitor, oncoprotein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 50099.14

Authors

Cederfelt, D.,Talibov, V.O.,Dobritzsch, D.,Danielson, U.H. (deposition date: 2020-04-27, release date: 2021-01-13, Last modification date: 2024-01-24)

• Primary citation: Talibov, V.O.,Fabini, E.,FitzGerald, E.A.,Tedesco, D.,Cederfeldt, D.,Talu, M.J.,Rachman, M.M.,Mihalic, F.,Manoni, E.,Naldi, M.,Sanese, P.,Forte, G.,Lepore Signorile, M.,Barril, X.,Simone, C.,Bartolini, M.,Dobritzsch, D.,Del Rio, A.,Danielson, U.H.; Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase.; Chembiochem, 22:1597-1608, 2021; PubMed: 33400854; DOI: 10.1002/cbic.202000736

Experimental method

X-RAY DIFFRACTION (1.93 Å)