6X0P
Ash1L SET domain Q2265A mutant in complex with AS-5
Summary for 6X0P
Entry DOI | 10.2210/pdb6x0p/pdb |
Descriptor | Histone-lysine N-methyltransferase ASH1L, 3-[6-(aminomethyl)-1-(2-hydroxyethyl)-1H-indol-3-yl]benzene-1-carbothioamide, ZINC ION, ... (5 entities in total) |
Functional Keywords | methyltransferase, complex, protein binding, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 107518.23 |
Authors | Rogawski, D.S.,Li, H.,Borkin, D.,Cierpicki, T.,Grembecka, J. (deposition date: 2020-05-17, release date: 2021-04-07, Last modification date: 2023-10-18) |
Primary citation | Rogawski, D.S.,Deng, J.,Li, H.,Miao, H.,Borkin, D.,Purohit, T.,Song, J.,Chase, J.,Li, S.,Ndoj, J.,Klossowski, S.,Kim, E.,Mao, F.,Zhou, B.,Ropa, J.,Krotoska, M.Z.,Jin, Z.,Ernst, P.,Feng, X.,Huang, G.,Nishioka, K.,Kelly, S.,He, M.,Wen, B.,Sun, D.,Muntean, A.,Dou, Y.,Maillard, I.,Cierpicki, T.,Grembecka, J. Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun, 12:2792-2792, 2021 Cited by PubMed: 33990599DOI: 10.1038/s41467-021-23152-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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