6X0P
Ash1L SET domain Q2265A mutant in complex with AS-5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone-lysine N-methyltransferase ASH1L | polymer | 226 | 25959.5 | 4 | UniProt (Q9NR48) Pfam (PF17907) Pfam (PF00856) | Homo sapiens (Human) | ASH1-like protein,huASH1,Absent small and homeotic disks protein 1 homolog,Lysine N-methyltransferase 2H |
| 2 | E, J, O, T (A, B, C, D) | 3-[6-(aminomethyl)-1-(2-hydroxyethyl)-1H-indol-3-yl]benzene-1-carbothioamide | non-polymer | 325.4 | 4 | Chemie (UK7) | |||
| 3 | F, G, H, K, L... (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 12 | Chemie (ZN) | |||
| 4 | I, N, S, X (A, B, C, D) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 4 | Chemie (SAM) | |||
| 5 | AA, BA, Y, Z (C, D, A, B) | water | water | 18.0 | 1071 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2069 - 2288 (UniProt: Q9NR48)
| PDB | External Database | Details |
|---|---|---|
| Gly 2063 | - | expression tag |
| Ala 2064 | - | expression tag |
| Met 2065 | - | expression tag |
| Ala 2066 | - | expression tag |
| Gly 2067 | - | expression tag |
| Ser 2068 | - | expression tag |
| Ala 2265 | Gln 2270 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 103837.9 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 3680.4 | |
| All* | Total formula weight | 107518.2 |
