6X0P

Ash1L SET domain Q2265A mutant in complex with AS-5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0042054	molecular_function	histone methyltransferase activity
B	0005634	cellular_component	nucleus
B	0042054	molecular_function	histone methyltransferase activity
C	0005634	cellular_component	nucleus
C	0042054	molecular_function	histone methyltransferase activity
D	0005634	cellular_component	nucleus
D	0042054	molecular_function	histone methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue UK7 A 2301

Chain	Residue
A	HIS2193
A	ILE2279
A	GLY2280
A	GLY2281
A	HOH2464
A	HOH2562
A	HOH2566
A	CYS2195
A	TYR2255
A	ASN2256
A	SER2259
A	PHE2260
A	ASN2261
A	LYS2264
A	GLN2266

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 2302

Chain	Residue
A	CYS2091
A	CYS2093
A	CYS2104
A	CYS2108

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 2303

Chain	Residue
A	CYS2104
A	CYS2117
A	CYS2122
A	CYS2128

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 2304

Chain	Residue
A	CYS2220
A	CYS2268
A	CYS2270
A	CYS2275

---

site_id	AC5
Number of Residues	23
Details	binding site for residue SAM A 2305

Chain	Residue
A	LYS2150
A	GLY2151
A	TRP2152
A	SER2191
A	ASP2192
A	HIS2193
A	TYR2194
A	ARG2214
A	PHE2215
A	ASN2217
A	HIS2218
A	TYR2255
A	GLN2266
A	LEU2267
A	CYS2268
A	LYS2269
A	ILE2279
A	HOH2413
A	HOH2436
A	HOH2450
A	HOH2472
A	HOH2482
A	HOH2570

---

site_id	AC6
Number of Residues	14
Details	binding site for residue UK7 B 2301

Chain	Residue
B	HIS2193
B	CYS2195
B	TYR2255
B	ASN2256
B	SER2259
B	PHE2260
B	ASN2261
B	VAL2262
B	LYS2264
B	GLN2266
B	ILE2278
B	ILE2279
B	GLY2280
B	SAM2305

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN B 2302

Chain	Residue
B	CYS2091
B	CYS2093
B	CYS2104
B	CYS2108

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN B 2303

Chain	Residue
B	CYS2104
B	CYS2117
B	CYS2122
B	CYS2128

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN B 2304

Chain	Residue
B	CYS2220
B	CYS2268
B	CYS2270
B	CYS2275

---

site_id	AD1
Number of Residues	22
Details	binding site for residue SAM B 2305

Chain	Residue
B	LYS2150
B	GLY2151
B	TRP2152
B	SER2191
B	ASP2192
B	HIS2193
B	TYR2194
B	ARG2214
B	PHE2215
B	ASN2217
B	HIS2218
B	TYR2255
B	GLN2266
B	LEU2267
B	CYS2268
B	LYS2269
B	ILE2279
B	UK72301
B	HOH2413
B	HOH2424
B	HOH2430
B	HOH2501

---

site_id	AD2
Number of Residues	15
Details	binding site for residue UK7 C 2301

Chain	Residue
C	CYS2195
C	TYR2255
C	ASN2256
C	SER2259
C	PHE2260
C	ASN2261
C	LYS2264
C	GLN2266
C	ILE2278
C	ILE2279
C	GLY2280
C	HOH2456
C	HOH2480
C	HOH2501
C	HIS2193

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN C 2302

Chain	Residue
C	CYS2091
C	CYS2093
C	CYS2104
C	CYS2108

---

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN C 2303

Chain	Residue
C	CYS2104
C	CYS2117
C	CYS2122
C	CYS2128

---

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN C 2304

Chain	Residue
C	CYS2220
C	CYS2268
C	CYS2270
C	CYS2275

---

site_id	AD6
Number of Residues	23
Details	binding site for residue SAM C 2305

Chain	Residue
C	LYS2150
C	GLY2151
C	TRP2152
C	SER2191
C	ASP2192
C	HIS2193
C	TYR2194
C	ARG2214
C	PHE2215
C	ASN2217
C	HIS2218
C	TYR2255
C	GLN2266
C	LEU2267
C	CYS2268
C	LYS2269
C	ILE2279
C	HOH2414
C	HOH2436
C	HOH2477
C	HOH2483
C	HOH2542
C	HOH2583

---

site_id	AD7
Number of Residues	16
Details	binding site for residue UK7 D 2301

Chain	Residue
D	HIS2193
D	CYS2195
D	TYR2255
D	ASN2256
D	SER2259
D	PHE2260
D	ASN2261
D	VAL2262
D	LYS2264
D	GLN2266
D	ILE2278
D	ILE2279
D	GLY2280
D	GLY2281
D	SAM2305
D	HOH2562

---

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN D 2302

Chain	Residue
D	CYS2091
D	CYS2093
D	CYS2104
D	CYS2108

---

site_id	AD9
Number of Residues	4
Details	binding site for residue ZN D 2303

Chain	Residue
D	CYS2104
D	CYS2117
D	CYS2122
D	CYS2128

---

site_id	AE1
Number of Residues	4
Details	binding site for residue ZN D 2304

Chain	Residue
D	CYS2220
D	CYS2268
D	CYS2270
D	CYS2275

---

site_id	AE2
Number of Residues	22
Details	binding site for residue SAM D 2305

Chain	Residue
D	LYS2150
D	TRP2152
D	SER2191
D	ASP2192
D	HIS2193
D	TYR2194
D	ARG2214
D	PHE2215
D	ASN2217
D	HIS2218
D	TYR2255
D	GLN2266
D	LEU2267
D	CYS2268
D	LYS2269
D	ILE2279
D	UK72301
D	HOH2421
D	HOH2459
D	HOH2484
D	HOH2528
D	HOH2576

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	204
Details	Domain: {"description":"AWS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00562","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	464
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	64
Details	Domain: {"description":"Post-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00155","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---