7BJ1

Crystal structure of SMYD3 with diperodon S enantiomer bound to allosteric site

Replaces:  6Z2R

Summary for 7BJ1

• Entry DOI: 10.2210/pdb7bj1/pdb
• Descriptor: Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, Diperodon (S-enantiomer), ... (7 entities in total)
• Functional Keywords: methyltransferase, complex, inhibitor, oncoprotein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 50754.81

Authors

Talibov, V.O.,Cederfelt, D.,Dobritzsch, D.,Danielson, U.H. (deposition date: 2021-01-13, release date: 2021-03-03, Last modification date: 2024-01-31)

• Primary citation: Talibov, V.O.,Fabini, E.,FitzGerald, E.A.,Tedesco, D.,Cederfeldt, D.,Talu, M.J.,Rachman, M.M.,Mihalic, F.,Manoni, E.,Naldi, M.,Sanese, P.,Forte, G.,Barril, X.,Simone, C.,Bartolini, M.,Dobritzsch, D.,Danielson, U.H.; Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase; Chembiochem, 22:1597-1608, 2021; DOI: 10.1002/cbic.202000736

Experimental method

X-RAY DIFFRACTION (1.61 Å)