7BRE

The crystal structure of MLL2 in complex with ASH2L and RBBP5

Summary for 7BRE

• Entry DOI: 10.2210/pdb7bre/pdb
• Descriptor: Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2B, Retinoblastoma-binding protein 5, ... (5 entities in total)
• Functional Keywords: histone methyltransferase, mll2 complex, mll2, rbbp5, ash2l, histone methylation, epigenetics, protein binding, non-histone substrate, p53
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 86679.29

Authors

Li, Y.,Zhao, L.,Chen, Y. (deposition date: 2020-03-28, release date: 2020-07-22, Last modification date: 2023-11-29)

• Primary citation: Li, Y.,Zhao, L.,Tian, X.,Peng, C.,Gong, F.,Chen, Y.; Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases.; Structure, 28:1141-, 2020; PubMed: 32697937; DOI: 10.1016/j.str.2020.07.002

Experimental method

X-RAY DIFFRACTION (2.803 Å)