7BRE
The crystal structure of MLL2 in complex with ASH2L and RBBP5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Set1/Ash2 histone methyltransferase complex subunit ASH2 | polymer | 184 | 20597.4 | 2 | UniProt (Q9UBL3) Pfam (PF00622) | Homo sapiens (Human) | ASH2-like protein |
| 2 | B, C (B, E) | Histone-lysine N-methyltransferase 2B | polymer | 165 | 19037.1 | 2 | UniProt (Q9UMN6) Pfam (PF00856) | Homo sapiens (Human) | Lysine N-methyltransferase 2B,Myeloid/lymphoid or mixed-lineage leukemia protein 4,Trithorax homolog 2,WW domain-binding protein 7,WBP-7 |
| 3 | E, F (C, F) | Retinoblastoma-binding protein 5 | polymer | 27 | 3255.3 | 2 | UniProt (Q15291) | Homo sapiens (Human) | RBBP-5,Retinoblastoma-binding protein RBQ-3 |
| 4 | G, I (B, E) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | H, J (B, E) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) |
Sequence modifications
A, D: 286 - 402 (UniProt: Q9UBL3)
A, D: 445 - 504 (UniProt: Q9UBL3)
| PDB | External Database | Details |
|---|---|---|
| Ser 285 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ile 439 | - | linker |
| Ser 440 | - | linker |
| Gly 441 | - | linker |
| Arg 442 | - | linker |
| Gly 443 | - | linker |
| Ser 444 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 85779.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 899.6 | |
| All* | Total formula weight | 86679.3 |
