7BRE

The crystal structure of MLL2 in complex with ASH2L and RBBP5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0048188	cellular_component	Set1C/COMPASS complex
D	0048188	cellular_component	Set1C/COMPASS complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN B 2801

Chain	Residue
B	CYS2655
B	CYS2703
B	CYS2705
B	CYS2710

---

site_id	AC2
Number of Residues	14
Details	binding site for residue SAH B 2802

Chain	Residue
B	PHE2650
B	ILE2651
B	ASN2652
B	HIS2653
B	TYR2690
B	PRO2702
B	CYS2703
B	ASN2704
E	ARG2553
B	ILE2584
B	HIS2585
B	ARG2587
B	TYR2629
B	ARG2649

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN E 2801

Chain	Residue
E	CYS2655
E	CYS2703
E	CYS2705
E	CYS2710

---

site_id	AC4
Number of Residues	12
Details	binding site for residue SAH E 2802

Chain	Residue
B	ARG2553
E	ILE2584
E	HIS2585
E	GLY2586
E	ARG2587
E	TYR2629
E	ARG2649
E	ASN2652
E	HIS2653
E	PRO2702
E	CYS2703
E	ASN2704

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	232
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q03164","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Domain: {"description":"Post-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00155","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---