PDB: 70 resultsInfo pagesStatus searchChemie searchBIRD

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2QVW	Structure of Giardia Dicer refined against twinned data Descriptor: GLP_546_48378_50642, MANGANESE (II) ION Authors: Doudna, J.A, MacRae, I.J. Deposit date: 2007-08-09 Release date: 2007-09-25 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer Acta Crystallogr.,Sect.D, 63, 2007
7XW2	Cryo-EM structure of human DICER-pre-miRNA in a dicing state Descriptor: CALCIUM ION, Endoribonuclease Dicer, RNA (73-MER) Authors: Lee, H, Roh, S.-H. Deposit date: 2022-05-26 Release date: 2023-03-08 Last modified: 2023-03-22 Method: ELECTRON MICROSCOPY (3.04 Å) Cite: Structure of the human DICER-pre-miRNA complex in a dicing state. Nature, 615, 2023
8DFV	Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex IIa Descriptor: CALCIUM ION, Endoribonuclease Dcr-1, Loquacious, ... Authors: Jouravleva, K, Golovenko, D, Demo, G, Dutcher, R.C, Tanaka Hall, T.M, Zamore, P.D, Korostelev, A.A. Deposit date: 2022-06-22 Release date: 2022-11-16 Method: ELECTRON MICROSCOPY (3.06 Å) Cite: Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB. Mol.Cell, 82, 2022
6TNN	Mini-RNase III (Mini-III) bound to 50S ribosome with precursor 23S rRNA Descriptor: 50S ribosomal protein L10, 50S ribosomal protein L13, 50S ribosomal protein L14, ... Authors: Oerum, S, Dendooven, T, Gilet, L, Catala, M, Degut, C, Trinquier, A, Barraud, P, Luisi, B, Condon, C, Tisne, C. Deposit date: 2019-12-09 Release date: 2020-09-30 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.07 Å) Cite: Structures of B. subtilis Maturation RNases Captured on 50S Ribosome with Pre-rRNAs. Mol.Cell, 80, 2020
7VG2	Cryo-EM structure of Arabidopsis DCL3 in complex with a 40-bp RNA Descriptor: CALCIUM ION, Dicer-like 3, TAS1a forward strand (5'-phosphorylation), ... Authors: Wang, Q, Du, J. Deposit date: 2021-09-14 Release date: 2021-10-27 Last modified: 2021-12-15 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation. Science, 374, 2021
7W0A	dmDicer2-LoqsPD-dsRNA Dimer status Descriptor: Dicer-2, isoform A, Loquacious, ... Authors: Su, S, Wang, J, Wang, H.W, Ma, J. Deposit date: 2021-11-18 Release date: 2022-04-27 Last modified: 2022-07-27 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
3J6B	Structure of the yeast mitochondrial large ribosomal subunit Descriptor: 21S ribosomal RNA, 54S ribosomal protein IMG1, mitochondrial, ... Authors: Amunts, A, Brown, A, Bai, X.C, Llacer, J.L, Hussain, T, Emsley, P, Long, F, Murshudov, G, Scheres, S.H.W, Ramakrishnan, V. Deposit date: 2014-01-22 Release date: 2014-04-09 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structure of the yeast mitochondrial large ribosomal subunit. Science, 343, 2014
5B16	X-ray structure of DROSHA in complex with the C-terminal tail of DGCR8. Descriptor: Microprocessor complex subunit DGCR8, Ribonuclease 3,DROSHA,Ribonuclease 3,DROSHA,Ribonuclease 3, ZINC ION Authors: Kwon, S.C, Nguyen, T.A, Choi, Y.G, Jo, M.H, Hohng, S, Kim, V.N, Woo, J.S. Deposit date: 2015-11-23 Release date: 2016-02-03 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structure of Human DROSHA Cell, 164, 2016
5MRC	Structure of the yeast mitochondrial ribosome - Class A Descriptor: 15S ribosomal RNA, 21S ribosomal RNA, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Desai, N, Brown, A, Amunts, A, Ramakrishnan, V. Deposit date: 2016-12-22 Release date: 2017-02-15 Last modified: 2018-02-07 Method: ELECTRON MICROSCOPY (3.25 Å) Cite: The structure of the yeast mitochondrial ribosome. Science, 355, 2017
8DG5	Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex IIb Descriptor: Endoribonuclease Dcr-1, Loquacious, isoform B, ... Authors: Jouravleva, K, Golovenko, D, Demo, G, Dutcher, R.C, Tanaka Hall, T.M, Zamore, P.D, Korostelev, A.A. Deposit date: 2022-06-23 Release date: 2022-11-16 Method: ELECTRON MICROSCOPY (3.26 Å) Cite: Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB. Mol.Cell, 82, 2022
7V6C	Structure of the Dicer-2-R2D2 heterodimer bound to small RNA duplex Descriptor: Dicer-2, isoform A, R2D2, ... Authors: Yamaguchi, S, Nishizawa, T, Kusakizako, T, Yamashita, K, Tomita, A, Hirano, H, Nishimasu, H, Nureki, O. Deposit date: 2021-08-20 Release date: 2022-03-23 Last modified: 2022-07-27 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex. Nature, 607, 2022
7V6B	Structure of the Dicer-2-R2D2 heterodimer Descriptor: Dicer-2, isoform A, R2D2 Authors: Yamaguchi, S, Nishizawa, T, Kusakizako, T, Yamashita, K, Tomita, A, Hirano, H, Nishimasu, H, Nureki, O. Deposit date: 2021-08-20 Release date: 2022-03-23 Last modified: 2022-07-27 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex. Nature, 607, 2022
8DG7	Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex III Descriptor: Endoribonuclease Dcr-1, Loquacious, isoform B, ... Authors: Jouravleva, K, Golovenko, D, Demo, G, Dutcher, R.C, Tanaka Hall, T.M, Zamore, P.D, Korostelev, A.A. Deposit date: 2022-06-23 Release date: 2022-11-16 Method: ELECTRON MICROSCOPY (3.32 Å) Cite: Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB. Mol.Cell, 82, 2022
7W0B	Dicer2-LoqsPD complex at apo status Descriptor: Dicer-2, isoform A, Loquacious, ... Authors: Su, S, Wang, J, Wang, H.W, Ma, J. Deposit date: 2021-11-18 Release date: 2022-04-27 Last modified: 2022-07-27 Method: ELECTRON MICROSCOPY (3.33 Å) Cite: Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
2FFL	Crystal Structure of Dicer from Giardia intestinalis Descriptor: Dicer, MANGANESE (II) ION Authors: Doudna, J.A, MacRae, I.J, Adams, P.D. Deposit date: 2005-12-19 Release date: 2006-01-24 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3.33 Å) Cite: Structural Basis of Double-Stranded RNA Processing by Dicer Science, 311, 2006
8HF1	DmDcr-2/R2D2/LoqsPD with 19bp-dsRNA in Trimer state Descriptor: Dicer-2, isoform A, LD06392p, ... Authors: Su, S, Wang, J, Ma, J. Deposit date: 2022-11-09 Release date: 2023-09-06 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural mechanism of R2D2 and Loqs-PD synergistic modulation on DmDcr-2 oligomers. Nat Commun, 14, 2023
6V5B	Human Drosha and DGCR8 in complex with Primary MicroRNA (MP/RNA complex) - Active state Descriptor: CALCIUM ION, Microprocessor complex subunit DGCR8, Pri-miR-16-2 (78-MER), ... Authors: Partin, A, Zhang, K, Jeong, B, Herrell, E, Li, S, Chiu, W, Nam, Y. Deposit date: 2019-12-04 Release date: 2020-04-08 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA. Mol.Cell, 78, 2020
8HF0	DmDcr-2/R2D2/LoqsPD with 50bp-dsRNA in Dimer state Descriptor: Dicer-2, isoform A, LD06392p, ... Authors: Su, S, Wang, J, Wang, H.W, Ma, J. Deposit date: 2022-11-09 Release date: 2023-09-06 Method: ELECTRON MICROSCOPY (3.72 Å) Cite: Structural mechanism of R2D2 and Loqs-PD synergistic modulation on DmDcr-2 oligomers. Nat Commun, 14, 2023
8DGA	Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex IV Descriptor: Endoribonuclease Dcr-1, Loquacious, isoform B, ... Authors: Jouravleva, K, Golovenko, D, Demo, G, Dutcher, R.C, Tanaka Hall, T.M, Zamore, P.D, Korostelev, A.A. Deposit date: 2022-06-23 Release date: 2022-11-16 Method: ELECTRON MICROSCOPY (3.73 Å) Cite: Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB. Mol.Cell, 82, 2022
7VG3	Cryo-EM structure of Arabidopsis DCL3 in complex with a 30-bp RNA Descriptor: CALCIUM ION, Dicer-like 3, TAS1a RNA forward strand (5'-phosphorylated), ... Authors: Wang, Q, Du, J. Deposit date: 2021-09-14 Release date: 2021-10-27 Last modified: 2021-12-15 Method: ELECTRON MICROSCOPY (3.73 Å) Cite: Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation. Science, 374, 2021
5MRE	Structure of the yeast mitochondrial ribosome - Class B Descriptor: 15S ribosomal RNA, 21S ribosomal RNA, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Desai, N, Brown, A, Amunts, A, Ramakrishnan, V. Deposit date: 2016-12-22 Release date: 2017-02-15 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.75 Å) Cite: The structure of the yeast mitochondrial ribosome. Science, 355, 2017
7ZPK	Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate and TARBP2 subunit Descriptor: 59-nt precursor of miR-15a, Endoribonuclease Dicer, RISC-loading complex subunit TARBP2 Authors: Zanova, M, Zapletal, D, Kubicek, K, Stefl, R, Pinkas, M, Novacek, J. Deposit date: 2022-04-27 Release date: 2022-11-16 Method: ELECTRON MICROSCOPY (3.81 Å) Cite: Structural and functional basis of mammalian microRNA biogenesis by Dicer. Mol.Cell, 82, 2022
7ZPJ	Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate and TARBP2 subunit Descriptor: 59-nt precursor of miR-15a, Endoribonuclease Dicer, RISC-loading complex subunit TARBP2 isoform 1 Authors: Zanova, M, Zapletal, D, Kubicek, K, Stefl, R, Pinkas, M, Novacek, J. Deposit date: 2022-04-27 Release date: 2022-12-28 Method: ELECTRON MICROSCOPY (3.81 Å) Cite: Structural and functional basis of mammalian microRNA biogenesis by Dicer. Mol.Cell, 82, 2022
7YZ4	Mouse endoribonuclease Dicer (composite structure) Descriptor: Endoribonuclease Dicer Authors: Zanova, M, Zapletal, D, Kubicek, K, Stefl, R, Pinkas, M, Novacek, J. Deposit date: 2022-02-18 Release date: 2022-11-16 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: Structural and functional basis of mammalian microRNA biogenesis by Dicer. Mol.Cell, 82, 2022
6LXD	Pri-miRNA bound DROSHA-DGCR8 complex Descriptor: Microprocessor complex subunit DGCR8, RNA (102-mer), Ribonuclease 3, ... Authors: Jin, W, Wang, J, Liu, C.P, Wang, H.W, Xu, R.M. Deposit date: 2020-02-10 Release date: 2020-04-15 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural Basis for pri-miRNA Recognition by Drosha. Mol.Cell, 78, 2020

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