7ZPK

Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate and TARBP2 subunit

Summary for 7ZPK

Entry DOI	10.2210/pdb7zpk/pdb
EMDB information	14383 14384 14387 14856
Descriptor	Endoribonuclease Dicer, 59-nt precursor of miR-15a, RISC-loading complex subunit TARBP2 (3 entities in total)
Functional Keywords	endoribonuclease, dsrna, complex, gene silencing, post-transcriptional, catalytic complex, cytoplasm, risc-loading complex, tarbp2 rna binding protein, rna binding protein
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	3
Total formula weight	285933.99
Authors	Zanova, M.,Zapletal, D.,Kubicek, K.,Stefl, R.,Pinkas, M.,Novacek, J. (deposition date: 2022-04-27, release date: 2022-11-16)
Primary citation	Zapletal, D.,Taborska, E.,Pasulka, J.,Malik, R.,Kubicek, K.,Zanova, M.,Much, C.,Sebesta, M.,Buccheri, V.,Horvat, F.,Jenickova, I.,Prochazkova, M.,Prochazka, J.,Pinkas, M.,Novacek, J.,Joseph, D.F.,Sedlacek, R.,Bernecky, C.,O'Carroll, D.,Stefl, R.,Svoboda, P. Structural and functional basis of mammalian microRNA biogenesis by Dicer. Mol.Cell, 82:4064-4079.e13, 2022 Cited by PubMed: 36332606 DOI: 10.1016/j.molcel.2022.10.010 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.81 Å)

Structure validation