7ZPK
Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate and TARBP2 subunit
Summary for 7ZPK
Entry DOI | 10.2210/pdb7zpk/pdb |
EMDB information | 14383 14384 14387 14856 |
Descriptor | Endoribonuclease Dicer, 59-nt precursor of miR-15a, RISC-loading complex subunit TARBP2 (3 entities in total) |
Functional Keywords | endoribonuclease, dsrna, complex, gene silencing, post-transcriptional, catalytic complex, cytoplasm, risc-loading complex, tarbp2 rna binding protein, rna binding protein |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 3 |
Total formula weight | 285933.99 |
Authors | Zanova, M.,Zapletal, D.,Kubicek, K.,Stefl, R.,Pinkas, M.,Novacek, J. (deposition date: 2022-04-27, release date: 2022-11-16, Last modification date: 2024-07-24) |
Primary citation | Zapletal, D.,Taborska, E.,Pasulka, J.,Malik, R.,Kubicek, K.,Zanova, M.,Much, C.,Sebesta, M.,Buccheri, V.,Horvat, F.,Jenickova, I.,Prochazkova, M.,Prochazka, J.,Pinkas, M.,Novacek, J.,Joseph, D.F.,Sedlacek, R.,Bernecky, C.,O'Carroll, D.,Stefl, R.,Svoboda, P. Structural and functional basis of mammalian microRNA biogenesis by Dicer. Mol.Cell, 82:4064-4079.e13, 2022 Cited by PubMed: 36332606DOI: 10.1016/j.molcel.2022.10.010 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.81 Å) |
Structure validation
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