5MRC
Structure of the yeast mitochondrial ribosome - Class A
This is a non-PDB format compatible entry.
Summary for 5MRC
| Entry DOI | 10.2210/pdb5mrc/pdb |
| EMDB information | 2566 3551 |
| Descriptor | 21S ribosomal RNA, uL15m, uL16m, ... (82 entities in total) |
| Functional Keywords | yeast, mitochondrial, ribosome, saccharomyces cerevisiae |
| Biological source | Saccharomyces cerevisiae (Baker's yeast) More |
| Cellular location | Mitochondrion : P32611 P31334 P51998 P36519 P32904 P53724 Q12487 P35996 P36520 P38064 P22353 P25626 P40858 P53881 P32387 P36534 P12687 P36525 P36517 P20084 P36531 P25348 P36533 Q04598 P53921 O14464 Q06678 P36527 P36526 Q06090 P36516 P36528 P25642 Q02204 P36523 P22354 P23369 P14063 Q02950 P32902 P02381 P27929 P33759 P28778 P47150 Q03799 P38120 Q03201 P42847 P53732 P53937 P10663 P21771 Q02608 Q03246 P40033 P53733 P38175 P40496 P17558 Q01163 P53305 Q03976 O75012 P32344 P38783 P47141 P10662 P12686 P53292 Q03430 P28817 Nucleus : Q06630 |
| Total number of polymer chains | 78 |
| Total formula weight | 3325585.75 |
| Authors | Desai, N.,Brown, A.,Amunts, A.,Ramakrishnan, V. (deposition date: 2016-12-22, release date: 2017-02-15, Last modification date: 2025-04-09) |
| Primary citation | Desai, N.,Brown, A.,Amunts, A.,Ramakrishnan, V. The structure of the yeast mitochondrial ribosome. Science, 355:528-531, 2017 Cited by PubMed Abstract: Mitochondria have specialized ribosomes (mitoribosomes) dedicated to the expression of the genetic information encoded by their genomes. Here, using electron cryomicroscopy, we have determined the structure of the 75-component yeast mitoribosome to an overall resolution of 3.3 angstroms. The mitoribosomal small subunit has been built de novo and includes 15S ribosomal RNA (rRNA) and 34 proteins, including 14 without homologs in the evolutionarily related bacterial ribosome. Yeast-specific rRNA and protein elements, including the acquisition of a putatively active enzyme, give the mitoribosome a distinct architecture compared to the mammalian mitoribosome. At an expanded messenger RNA channel exit, there is a binding platform for translational activators that regulate translation in yeast but not mammalian mitochondria. The structure provides insights into the evolution and species-specific specialization of mitochondrial translation. PubMed: 28154081DOI: 10.1126/science.aal2415 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.25 Å) |
Structure validation
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