8SOC
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8SOD
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8XGR
| ETB-eGt complex bound to endothelin-1 | 分子名称: | Camelid antibody VHH fragment, Endothelin receptor type B, Endothelin-1, ... | 著者 | Oshima, H.S, Sano, F.K, Akasaka, H, Iwama, A, Shihoya, W, Nureki, O. | 登録日 | 2023-12-15 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Optimizing cryo-EM structural analysis of G i -coupling receptors via engineered G t and Nb35 application. Biochem.Biophys.Res.Commun., 693, 2024
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8X2K
| a lipid receptor complex structure | 分子名称: | (Z)-N-(2-hydroxyethyl)octadec-9-enamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Geng, C, Yang, D, Jun, X. | 登録日 | 2023-11-09 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | a lipid receptor complex structure To Be Published
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8VY7
| CryoEM structure of Gi-coupled TAS2R14 with cholesterol and an intracellular tastant | 分子名称: | 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Kim, Y, Gumpper, R.H, Roth, B.L. | 登録日 | 2024-02-07 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | 主引用文献 | Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature, 628, 2024
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8VY9
| CryoEM structure of Ggust-coupled TAS2R14 with cholesterol and an intracellular tastant | 分子名称: | 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Kim, Y, Gumpper, R.H, Roth, B.L. | 登録日 | 2024-02-07 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature, 628, 2024
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8SOE
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8SL3
| Human adenylyl Cyclase 5 in complex with Gbg | 分子名称: | Adenylate cyclase type 5, GERAN-8-YL GERAN, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Yen, Y.C, Tesmer, J.J.G. | 登録日 | 2023-04-20 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (7 Å) | 主引用文献 | Structure of adenylyl cyclase 5 in complex with G beta gamma offers insights into ADCY5-related dyskinesia. Nat.Struct.Mol.Biol., 2024
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8J6I
| Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892 | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. | 登録日 | 2023-04-26 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
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8J6L
| Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound niacin | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. | 登録日 | 2023-04-26 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
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8XZG
| Cryo-EM structure of the [Pyr1]-apelin-13-bound human APLNR-Gi complex | 分子名称: | Apelin receptor, Apelin-13, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wang, W, Ji, S, Zhang, Y. | 登録日 | 2024-01-21 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure-based design of non-hypertrophic apelin receptor modulator. Cell, 187, 2024
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8IU2
| Cryo-EM structure of Long-wave-sensitive opsin 1 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Peng, Q, Cheng, X.Y, Li, J, Lu, Q.Y, Li, Y.Y, Zhang, J. | 登録日 | 2023-03-23 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Cryo-EM structure of Long-wave-sensitive opsin 1 To Be Published
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8XZI
| Cryo-EM structure of the CMF-019-bound human APLNR-Gi complex | 分子名称: | (3~{S})-5-methyl-3-[[1-pentan-3-yl-2-(thiophen-2-ylmethyl)benzimidazol-5-yl]carbonylamino]hexanoic acid, Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wang, W, Ji, S, Zhang, Y. | 登録日 | 2024-01-21 | 公開日 | 2024-03-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structure-based design of non-hypertrophic apelin receptor modulator. Cell, 187, 2024
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8XZJ
| Cryo-EM structure of the WN353-bound human APLNR-Gi complex | 分子名称: | Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, W, Ji, S, Zhang, Y. | 登録日 | 2024-01-21 | 公開日 | 2024-03-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure-based design of non-hypertrophic apelin receptor modulator. Cell, 187, 2024
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8XZF
| Cryo-EM structure of the WN561-bound human APLNR-Gi complex | 分子名称: | Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, W, Ji, S, Zhang, Y. | 登録日 | 2024-01-21 | 公開日 | 2024-03-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure-based design of non-hypertrophic apelin receptor modulator. Cell, 187, 2024
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8XZH
| Cryo-EM structure of the MM07-bound human APLNR-Gi complex | 分子名称: | Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, W, Ji, S, Zhang, Y. | 登録日 | 2024-01-21 | 公開日 | 2024-03-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structure-based design of non-hypertrophic apelin receptor modulator. Cell, 187, 2024
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8JXT
| Histamine-bound H4R/Gi complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | He, Y, Xia, R. | 登録日 | 2023-07-01 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Structural basis of ligand recognition and design of antihistamines targeting histamine H 4 receptor. Nat Commun, 15, 2024
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8JXW
| VUF6884-bound H4R/Gi complex | 分子名称: | 2-chloranyl-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | He, Y, Xia, R. | 登録日 | 2023-07-01 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structural basis of ligand recognition and design of antihistamines targeting histamine H 4 receptor. Nat Commun, 15, 2024
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8JXX
| Clobenpropit-bound H4R/Gi complex | 分子名称: | 3-(1~{H}-imidazol-4-yl)propyl ~{N}'-[(4-chlorophenyl)methyl]carbamimidothioate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | He, Y, Xia, R. | 登録日 | 2023-07-01 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structural basis of ligand recognition and design of antihistamines targeting histamine H 4 receptor. Nat Commun, 15, 2024
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8JXV
| Clozapine-bound H4R/Gi complex | 分子名称: | 3-chloranyl-6-(4-methylpiperazin-1-yl)-11~{H}-benzo[b][1,4]benzodiazepine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | He, Y, Xia, R. | 登録日 | 2023-07-01 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Structural basis of ligand recognition and design of antihistamines targeting histamine H 4 receptor. Nat Commun, 15, 2024
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8U4N
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8U4O
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8U4P
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8U4Q
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8X7A
| Treprostinil bound Prostacyclin Receptor G protein complex | 分子名称: | 2-[[(1~{R},2~{R},3~{a}~{S},9~{a}~{S})-2-oxidanyl-1-[(3~{S})-3-oxidanyloctyl]-2,3,3~{a},4,9,9~{a}-hexahydro-1~{H}-cyclopenta[g]naphthalen-5-yl]oxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, J.J, Jin, S, Zhang, H, Xu, Y, Hu, W, Jiang, Y, Chen, C, Wang, D.W, Xu, H.E, Wu, C. | 登録日 | 2023-11-23 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.56 Å) | 主引用文献 | Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs. Sci Adv, 10, 2024
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