8J6L

Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound niacin

Summary for 8J6L

• Entry DOI: 10.2210/pdb8j6l/pdb
• EMDB information: 36007
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: hydroxycarboxylic acid receptor 2, gpcr, niacin, mk-6892, gsk256073, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 170747.85

Authors

Yuan, Q.,Zhu, S.,Duan, J.,Xu, H.E.,Duan, X. (deposition date: 2023-04-26, release date: 2024-04-03)

• Primary citation: Zhu, S.,Yuan, Q.,Li, X.,He, X.,Shen, S.,Wang, D.,Li, J.,Cheng, X.,Duan, X.,Xu, H.E.,Duan, J.; Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2.; Cell Rep, 42:113406-113406, 2023; PubMed: 37952153; DOI: 10.1016/j.celrep.2023.113406

Experimental method

ELECTRON MICROSCOPY (3.05 Å)