8VY9

CryoEM structure of Ggust-coupled TAS2R14 with cholesterol and an intracellular tastant

This is a non-PDB format compatible entry.

Summary for 8VY9

• Entry DOI: 10.2210/pdb8vy9/pdb
• Related: 8VY7
• EMDB information: 43647 43650 43656
• Descriptor: Guanine nucleotide-binding protein G(t) subunit alpha-3, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: gpcr, complex, signaling protein, taste receptor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 193366.32

Authors

Kim, Y.,Gumpper, R.H.,Roth, B.L. (deposition date: 2024-02-07, release date: 2024-04-03, Last modification date: 2024-04-24)

• Primary citation: Kim, Y.,Gumpper, R.H.,Liu, Y.,Kocak, D.D.,Xiong, Y.,Cao, C.,Deng, Z.,Krumm, B.E.,Jain, M.K.,Zhang, S.,Jin, J.,Roth, B.L.; Bitter taste receptor activation by cholesterol and an intracellular tastant.; Nature, 628:664-671, 2024; PubMed: 38600377; DOI: 10.1038/s41586-024-07253-y

Experimental method

ELECTRON MICROSCOPY (2.88 Å)