7S8N
| CryoEM structure of Gq-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573 | 分子名称: | (3R)-N,N-dimethyl-1-[(8S)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-amine, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. | 登録日 | 2021-09-18 | 公開日 | 2021-11-17 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
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7PIU
| Cryo-EM structure of the agonist setmelanotide bound to the active melanocortin-4 receptor (MC4R) in complex with the heterotrimeric Gs protein at 2.6 A resolution. | 分子名称: | CALCIUM ION, Camelid antibody fragment - nanobody 35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Heyder, N.A, Schmidt, A, Kleinau, G, Hilal, T, Scheerer, P. | 登録日 | 2021-08-23 | 公開日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (2.58 Å) | 主引用文献 | Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide. Cell Res., 31, 2021
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7PIV
| Active Melanocortin-4 receptor (MC4R)- Gs protein complex bound to agonist NDP-alpha-MSH at 2.86 A resolution. | 分子名称: | CALCIUM ION, Camelid antibody VHH fragment - nanobody 35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Heyder, N.A, Schmidt, A, Kleinau, G, Hilal, T, Scheerer, P. | 登録日 | 2021-08-23 | 公開日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide. Cell Res., 31, 2021
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7VUZ
| Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, state2 | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-11-04 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VDM
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7VV5
| Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1 | 分子名称: | 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-11-04 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VDL
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7VUY
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7VDH
| Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state2 | 分子名称: | 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-09-07 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VV3
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7SHF
| Cryo-EM structure of GPR158 coupled to the RGS7-Gbeta5 complex | 分子名称: | (2S)-1-{[(S)-hydroxy{[(1s,2R,3R,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5E,8E,11E,14E)-icosa-5,8,11,14-tetraenoate, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHOLESTEROL, ... | 著者 | Patil, D.N, Singh, S, Singh, A.K, Martemyanov, K.A. | 登録日 | 2021-10-08 | 公開日 | 2021-12-01 | 最終更新日 | 2022-01-19 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G beta 5 signaling complex. Science, 375, 2022
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7EWR
| Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:2:2 ratio | 分子名称: | Guanine nucleotide-binding protein subunit beta-5, Probable G-protein coupled receptor 158, Regulator of G-protein signaling 7 | 著者 | Kim, Y, Jeong, E, Jeong, J, Cho, Y. | 登録日 | 2021-05-26 | 公開日 | 2021-12-01 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Structure of the class C orphan GPCR GPR158 in complex with RGS7-G beta 5. Nat Commun, 12, 2021
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7EWP
| Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:1:1 ratio | 分子名称: | Guanine nucleotide-binding protein subunit beta-5, Probable G-protein coupled receptor 158, Regulator of G-protein signaling 7 | 著者 | Kim, Y, Jeong, E, Jeong, J, Cho, Y. | 登録日 | 2021-05-25 | 公開日 | 2021-12-01 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structure of the class C orphan GPCR GPR158 in complex with RGS7-G beta 5. Nat Commun, 12, 2021
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7NA8
| Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist | 分子名称: | 1-(methanesulfonyl)-1'-(2-methyl-L-alanyl-O-benzyl-D-seryl)-1,2-dihydrospiro[indole-3,4'-piperidine], Antibody fragment, CHOLESTEROL, ... | 著者 | Liu, H, Sun, D, Sun, J, Zhang, C. | 登録日 | 2021-06-20 | 公開日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren Nat Commun, 12, 2021
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7NA7
| Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist | 分子名称: | Antibody fragment, CHOLESTEROL, Ghrelin-27, ... | 著者 | Liu, H, Sun, D, Sun, J, Zhang, C. | 登録日 | 2021-06-20 | 公開日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren Nat Commun, 12, 2021
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7P00
| Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex | 分子名称: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. | 登録日 | 2021-06-29 | 公開日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
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7P02
| Human Neurokinin 1 receptor (NK1R) substance P Gs complex | 分子名称: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. | 登録日 | 2021-06-29 | 公開日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | 主引用文献 | Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
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7VUJ
| Cryo-EM structure of a class A orphan GPCR | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | 登録日 | 2021-11-02 | 公開日 | 2021-12-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139. Cell Res., 32, 2022
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7VUG
| Cryo-EM structure of a class A orphan GPCR in complex with Gi | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, Chimera of Endo-1,4-beta-xylanase and Probable G-protein coupled receptor 139, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | 登録日 | 2021-11-02 | 公開日 | 2021-12-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139. Cell Res., 32, 2022
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7VUH
| Cryo-EM structure of a class A orphan GPCR | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | 登録日 | 2021-11-02 | 公開日 | 2021-12-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139. Cell Res., 32, 2022
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7VUI
| Cryo-EM structure of a class A orphan GPCR | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, Chimera of Endo-1,4-beta-xylanase and Probable G-protein coupled receptor 139, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | 登録日 | 2021-11-02 | 公開日 | 2021-12-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139. Cell Res., 32, 2022
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7S1M
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7S3I
| Ex4-D-Ala bound to the glucagon-like peptide-1 receptor/g protein complex (conformer 2) | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Belousoff, M.J, Piper, S.J, Danev, R. | 登録日 | 2021-09-07 | 公開日 | 2022-01-05 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (2.51 Å) | 主引用文献 | Structural and functional diversity among agonist-bound states of the GLP-1 receptor. Nat.Chem.Biol., 18, 2022
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7EO4
| Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to BAF312 | 分子名称: | 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | He, Y, Xu, Z, Ikuta, T, Inoue, A. | 登録日 | 2021-04-21 | 公開日 | 2022-01-05 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism. Nat.Chem.Biol., 18, 2022
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7EO2
| Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to FTY720p | 分子名称: | (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | He, Y, Xu, Z, Ikuta, T. | 登録日 | 2021-04-21 | 公開日 | 2022-01-05 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism. Nat.Chem.Biol., 18, 2022
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