7EO4

Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to BAF312

Summary for 7EO4

• Entry DOI: 10.2210/pdb7eo4/pdb
• EMDB information: 31226
• Descriptor: Sphingosine 1-phosphate receptor 1, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: gpcr, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 155930.35

Authors

He, Y.,Xu, Z.,Ikuta, T.,Inoue, A. (deposition date: 2021-04-21, release date: 2022-01-05, Last modification date: 2022-03-16)

• Primary citation: Xu, Z.,Ikuta, T.,Kawakami, K.,Kise, R.,Qian, Y.,Xia, R.,Sun, M.X.,Zhang, A.,Guo, C.,Cai, X.H.,Huang, Z.,Inoue, A.,He, Y.; Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism.; Nat.Chem.Biol., 18:281-288, 2022; PubMed: 34937912; DOI: 10.1038/s41589-021-00930-3

Experimental method

ELECTRON MICROSCOPY (2.86 Å)