7P00

Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex

Summary for 7P00

Entry DOI	10.2210/pdb7p00/pdb
EMDB information	13140
Descriptor	Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
Functional Keywords	receptor, complex, eukaryotic protein, membrane protein
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	6
Total formula weight	153615.19
Authors	Thom, C.,Ehrenmann, J.,Vacca, S.,Waltenspuhl, Y.,Schoppe, J.,Medalia, O.,Pluckthun, A. (deposition date: 2021-06-29, release date: 2021-12-15)
Primary citation	Thom, C.,Ehrenmann, J.,Vacca, S.,Waltenspuhl, Y.,Schoppe, J.,Medalia, O.,Pluckthun, A. Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7:eabk2872-eabk2872, 2021 Cited by PubMed: 34878828 DOI: 10.1126/sciadv.abk2872 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.71 Å)

Structure validation