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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7P00

Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(H)		Antibody fragment scFv16polymer29832409.21Mus musculus (Mouse)
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer35439086.61UniProt (P62873)
Pfam (PF25391)		Homo sapiens (Human)Transducin beta chain 1
3C
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (Human)G gamma-I
4D
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortpolymer24628304.21UniProt (P63096)
UniProt (A0A590UJY2)
Pfam (PF00503)
UniProt (by SIFTS) (P63092)		Homo sapiens (Human)Adenylate cyclase-inhibiting G alpha protein
5E
(R)		Substance-P receptorpolymer38244218.71UniProt (P25103)
Pfam (PF00001)		Homo sapiens (Human)SPR,NK-1 receptor,NK-1R,Tachykinin receptor 1
6F
(P)		Substance Ppolymer121348.61Pfam (PF02202)
UniProt (by SIFTS) (P20366)		Homo sapiens
7G
(R)		CHOLESTEROLnon-polymer386.71Chemie (CLR)
PubChem (304)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (638019)
PubChem (1549081)
PubChem (1553803)
PubChem (5283629)
PubChem (5284644)
PubChem (5315842)
PubChem (6419195)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (16219173)
PubChem (16758052)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (176980071)
PubChem (45044259)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (23423981)
PubChem (49853509)
PubChem (44654663)
PubChem (46937002)
PubChem (59274407)
PubChem (50990013)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (5997)
PubChem (1551269)
PubChem (90070115)
PubChem (52934537)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (56621683)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (132837164)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (57915018)
PubChem (57939063)
PubChem (138967089)
PubChem (58428240)
PubChem (58445498)
PubChem (139566851)
PubChem (58663286)
PubChem (15939944)
PubChem (59450329)
PubChem (59628412)
PubChem (171828367)
PubChem (173516975)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (89951918)
PubChem (90224410)
PubChem (91298236)
PubChem (101624109)
PubChem (124225449)
PubChem (124429284)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (130459183)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
Sequence modifications
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -13-initiating methionine
His -12-expression tag
His -11-expression tag
His -10-expression tag
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
A: 1 - 184 (UniProt: P63096)
PDBExternal DatabaseDetails
Glu 20Asp 20engineered mutation
Lys 21Arg 21engineered mutation
Gln 22Asn 22engineered mutation
Gln 24Arg 24engineered mutation
Lys 25Glu 25engineered mutation
Lys 27Gly 27engineered mutation
Gln 28Glu 28engineered mutation
Val 29Lys 29engineered mutation
Tyr 30Ala 30engineered mutation
Arg 31Ala 31engineered mutation
Ala 32Arg 32engineered mutation
Thr 33Glu 33engineered mutation
His 34Val 34engineered mutation
Arg 35Lys 35engineered mutation
Asp 42Gly 42engineered mutation
Asn 43Glu 43engineered mutation
Arg 185-linker
Ile 186-linker
Leu 187-linker
His 188-linker
Gly 189-linker
Gly 190-linker
Ser 191-linker
Gly 192-linker
Gly 193-linker
Ser 194-linker
Gly 195-linker
Gly 196-linker
Thr 197-linker
Ser 198-linker
Gly 199-linker
A: 200 - 377 (UniProt: A0A590UJY2)
PDBExternal DatabaseDetails
Asp 242Ala 92engineered mutation
Asp 245Ser 95engineered mutation
-Asn 97deletion
-Met 98deletion
-Val 99deletion
-Ile 100deletion
-Arg 101deletion
-Glu 102deletion
-Asp 103deletion
-Asn 104deletion
-Gln 105deletion
-Thr 106deletion
Ala 355Ile 215engineered mutation
Ile 358Val 218engineered mutation
Lys 363Arg 223engineered mutation
Leu 367Gln 227engineered mutation
Gln 368Arg 228engineered mutation
Asn 370His 230engineered mutation
Glu 373Gln 233engineered mutation
Asn 375Glu 235engineered mutation
Val 377Leu 237engineered mutation
R: 1 - 335 (UniProt: P25103)
PDBExternal DatabaseDetails
Met -46-initiating methionine
Lys -45-expression tag
Phe -44-expression tag
Leu -43-expression tag
Val -42-expression tag
Asn -41-expression tag
Val -40-expression tag
Ala -39-expression tag
Leu -38-expression tag
Val -37-expression tag
Phe -36-expression tag
Met -35-expression tag
Val -34-expression tag
Val -33-expression tag
Tyr -32-expression tag
Ile -31-expression tag
Ser -30-expression tag
Tyr -29-expression tag
Ile -28-expression tag
Tyr -27-expression tag
Ala -26-expression tag
Asp -25-expression tag
Tyr -24-expression tag
Lys -23-expression tag
Asp -22-expression tag
Asp -21-expression tag
Asp -20-expression tag
Asp -19-expression tag
Lys -18-expression tag
His -17-expression tag
His -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
His -11-expression tag
His -10-expression tag
His -9-expression tag
His -8-expression tag
Leu -7-expression tag
Glu -6-expression tag
Val -5-expression tag
Leu -4-expression tag
Phe -3-expression tag
Gln -2-expression tag
Gly -1-expression tag
Pro 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight153228.5
Non-Polymers*Number of molecules1
Total formula weight386.7
All*Total formula weight153615.2
*Water molecules are not included.

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PDB entries from 2026-04-08

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