3KJ0
| Mcl-1 in complex with Bim BH3 mutant I2dY | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Fire, E, Grant, R.A, Keating, A.E. | 登録日 | 2009-11-02 | 公開日 | 2010-02-16 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19, 2010
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3KJ1
| Mcl-1 in complex with Bim BH3 mutant I2dA | 分子名称: | ACETATE ION, Bcl-2-like protein 11, CHLORIDE ION, ... | 著者 | Fire, E, Grant, R.A, Keating, A.E. | 登録日 | 2009-11-02 | 公開日 | 2010-02-16 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.945 Å) | 主引用文献 | Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19, 2010
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3KJ2
| Mcl-1 in complex with Bim BH3 mutant F4aE | 分子名称: | ACETATE ION, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ... | 著者 | Fire, E, Grant, R.A, Keating, A.E. | 登録日 | 2009-11-02 | 公開日 | 2010-02-16 | 最終更新日 | 2021-10-13 | 実験手法 | X-RAY DIFFRACTION (2.351 Å) | 主引用文献 | Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19, 2010
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3KZ0
| MCL-1 complex with MCL-1-specific selected peptide | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 specific peptide MB7, SULFATE ION, ... | 著者 | Dutta, S, Fire, E, Grant, R.A, Sauer, R.T, Keating, A.E. | 登録日 | 2009-12-07 | 公開日 | 2010-05-05 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.349 Å) | 主引用文献 | Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL. J.Mol.Biol., 398, 2010
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2KUA
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2XA0
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3MK8
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3MQP
| Crystal Structure of human BFL-1 in complex with NOXA BH3 peptide, Northeast Structural Genomics Consortium Target HR2930 | 分子名称: | Bcl-2-related protein A1, Phorbol-12-myristate-13-acetate-induced protein 1 | 著者 | Guan, R, Xiao, R, Zhao, L, Acton, T.B, Gelinas, C, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2010-04-28 | 公開日 | 2010-06-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Crystal Structure of human BFL-1 in complex with NOXA BH3 peptide To be Published
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2XPX
| Crystal structure of BHRF1:Bak BH3 complex | 分子名称: | 1,2-ETHANEDIOL, APOPTOSIS REGULATOR BHRF1, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, ... | 著者 | Kvansakul, M, Huang, D.C.S, Colman, P.M. | 登録日 | 2010-08-31 | 公開日 | 2011-01-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus Bhrf1. Plos Pathog., 6, 2010
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3PK1
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3PL7
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3QBR
| BakBH3 in complex with sjA | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Bcl-2 homologous antagonist/killer, SJCHGC06286 protein | 著者 | Lee, E.F, Clarke, O.B, Fairlie, W.D, Colman, P.M, Evangelista, M, Feng, Z, Speed, T.P, Tchoubrieva, E, Strasser, A, Kalinna, B. | 登録日 | 2011-01-13 | 公開日 | 2011-04-13 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | 主引用文献 | Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes. Proc.Natl.Acad.Sci.USA, 108, 2011
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2Y6W
| Structure of a Bcl-w dimer | 分子名称: | BCL-2-LIKE PROTEIN 2, DI(HYDROXYETHYL)ETHER, TRIETHYLENE GLYCOL | 著者 | Lee, E.F, Evangelista, M, Pettikiriarachchi, A, Dogovski, C, Perugini, M.A, Colman, P.M, Fairlie, W.D. | 登録日 | 2011-01-27 | 公開日 | 2011-10-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of a Bcl-W Domain-Swapped Dimer: Implications for the Function of Bcl-2 Family Proteins. Structure, 19, 2011
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3QKD
| Crystal structure of Bcl-xL in complex with a Quinazoline sulfonamide inhibitor | 分子名称: | (R)-N-(7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4-yl)-4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrobenzenesulfonamide, Bcl-2-like protein 1, CHLORIDE ION, ... | 著者 | Czabotar, P.E, Smith, B.J. | 登録日 | 2011-01-31 | 公開日 | 2011-04-06 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity. J.Med.Chem., 54, 2011
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3R85
| Crystal structure of human SOUL BH3 domain in complex with Bcl-xL | 分子名称: | Bcl-2-like protein 1, Heme-binding protein 2, SULFATE ION | 著者 | Ambrosi, E.K, Capaldi, S, Bovi, M, Saccomani, G, Perduca, M, Monaco, H.L. | 登録日 | 2011-03-23 | 公開日 | 2011-06-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL. Biochem.J., 438, 2011
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2YJ1
| Puma BH3 foldamer in complex with Bcl-xL | 分子名称: | ALPHA-BETA-PUMA BH3 FOLDAMER, BCL-2-LIKE PROTEIN 1 | 著者 | Lee, E.F, Smith, B.J, Horne, W.S, Mayer, K.N, Evangelista, M, Colman, P.M, Gellman, S.H, Fairlie, W.D. | 登録日 | 2011-05-18 | 公開日 | 2011-10-12 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Structural Basis of Bcl-Xl Recognition by a Bh3-Mimetic Alpha-Beta-Peptide Generated Via Sequence-Based Design Chembiochem, 12, 2011
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3SP7
| Crystal Structure of Bcl-xL bound to BM903 | 分子名称: | 5-(4-chlorophenyl)-4-{3-[4-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]amino}phenyl)piperazin-1-yl]phenyl}-1,2-dimethyl-1H-pyrrole-3-carboxylic acid, ACETATE ION, Bcl-2-like protein 1, ... | 著者 | Meagher, J.L, Stuckey, J.A. | 登録日 | 2011-07-01 | 公開日 | 2012-07-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure-based design of a new class of potent Bcl-2/Bcl-xL inhibitors To be Published
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3SPF
| Crystal Structure of Bcl-xL bound to BM501 | 分子名称: | 4-(4-chlorophenyl)-1-[(3S)-3,4-dihydroxybutyl]-N-[3-(4-methylpiperazin-1-yl)propyl]-3-phenyl-1H-pyrrole-2-carboxamide, Bcl-2-like protein 1, GLYCEROL | 著者 | Meagher, J.L, Stuckey, J.A. | 登録日 | 2011-07-01 | 公開日 | 2012-06-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Design of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New Scaffold. J.Med.Chem., 55, 2012
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4A1U
| Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL | 分子名称: | ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1, CHLORIDE ION, ... | 著者 | Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D. | 登録日 | 2011-09-20 | 公開日 | 2011-12-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain. J.Am.Chem.Soc., 134, 2012
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4A1W
| Crystal structure of alpha-beta foldamer 4c in complex with Bcl-xL | 分子名称: | ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1 | 著者 | Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D. | 登録日 | 2011-09-20 | 公開日 | 2011-12-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.497 Å) | 主引用文献 | Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain. J.Am.Chem.Soc., 134, 2012
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2LP8
| SOLUTION STRUCTURE OF AN APOPTOSIS ACTIVATING PHOTOSWITCHABLE BAK PEPTIDE BOUND to BCL-XL | 分子名称: | 3,3'-(E)-diazene-1,2-diylbis{6-[(chloroacetyl)amino]benzenesulfonic acid}, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 1 | 著者 | Wysoczanski, P, Mart, R.J, Loveridge, J.E, Williams, C, Whittaker, S.B.-M, Crump, M.P, Allemann, R.K. | 登録日 | 2012-02-03 | 公開日 | 2012-04-18 | 最終更新日 | 2021-08-18 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-x(L). J.Am.Chem.Soc., 134, 2012
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2LPC
| NMR STRUCTURE of Bcl-XL | 分子名称: | Bcl-2-like protein 1 | 著者 | Wysoczanski, P, Mart, R.J, Loveridge, J.E, Williams, C, Whittaker, S.B.-M, Crump, M.P, Allemann, R.K. | 登録日 | 2012-02-09 | 公開日 | 2012-03-21 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-x(L). J.Am.Chem.Soc., 134, 2012
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2LR1
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4EHR
| Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide | 分子名称: | 4-[5-butyl-3-(hydroxymethyl)-1-phenyl-1H-pyrazol-4-yl]-3-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}benzamide, Bcl-2-like protein 1, IMIDAZOLE | 著者 | Schroeder, G.M, Wei, D, Banfi, P, Cai, Z, Lippy, J, Menichincheri, M, Modugno, M, Naglich, J, Penhallow, B, Perez, H.L, Sack, J, Schmidt, R.J, Tebben, A, Yan, C, Zhang, L, Galvani, A, Lombardo, L.J, Borzilleri, R.M. | 登録日 | 2012-04-03 | 公開日 | 2012-06-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists. Bioorg.Med.Chem.Lett., 22, 2012
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4AQ3
| HUMAN BCL-2 WITH PHENYLACYLSULFONAMIDE INHIBITOR | 分子名称: | APOPTOSIS REGULATOR BCL-2, BCL-2-LIKE PROTEIN 1, N,N-dibutyl-4-chloranyl-1-[2-(3,4-dihydro-1H-isoquinolin-2-ylcarbonyl)-4-[(7-iodanylnaphthalen-2-yl)sulfonylcarbamoyl]phenyl]-5-methyl-pyrazole-3-carboxamide | 著者 | Bertrand, J.A, Fasolini, M, Modugno, M. | 登録日 | 2012-04-12 | 公開日 | 2012-06-06 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Identification of a Phenylacylsulfonamide Series of Dual Bcl-2/Bcl-Xl Antagonists. Bioorg.Med.Chem.Lett., 22, 2012
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