4A1W

Crystal structure of alpha-beta foldamer 4c in complex with Bcl-xL

Summary for 4A1W

• Entry DOI: 10.2210/pdb4a1w/pdb
• Related: 4A1U
• Related PRD ID: PRD_000999
• Descriptor: BCL-2-LIKE PROTEIN 1, ALPHA-BETA-FOLDAMER 2C (3 entities in total)
• Functional Keywords: apoptosis-inhibitor complex, mimicry, apoptosis/inhibitor
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 8
• Total formula weight: 80982.48

Authors

Boersma, M.D.,Haase, H.S.,Kaufman, K.J.,Horne, W.S.,Lee, E.F.,Clarke, O.B.,Smith, B.J.,Colman, P.M.,Gellman, S.H.,Fairlie, W.D. (deposition date: 2011-09-20, release date: 2011-12-28, Last modification date: 2023-12-20)

• Primary citation: Boersma, M.D.,Haase, H.S.,Peterson-Kaufman, K.J.,Lee, E.F.,Clarke, O.B.,Colman, P.M.,Smith, B.J.,Horne, W.S.,Fairlie, W.D.,Gellman, S.H.; Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain.; J.Am.Chem.Soc., 134:315-, 2012; PubMed: 22040025; DOI: 10.1021/JA207148M

Experimental method

X-RAY DIFFRACTION (2.497 Å)