3KZ0

MCL-1 complex with MCL-1-specific selected peptide

Summary for 3KZ0

Entry DOI	10.2210/pdb3kz0/pdb
Descriptor	Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 specific peptide MB7, ZINC ION, ... (5 entities in total)
Functional Keywords	bcl-2, bh3, mitochondrion, apoptosis, anti-apoptotic
Biological source	Homo sapiens (human) More
Cellular location	Membrane ; Single-pass membrane protein : Q07820
Total number of polymer chains	4
Total formula weight	42020.77
Authors	Dutta, S.,Fire, E.,Grant, R.A.,Sauer, R.T.,Keating, A.E. (deposition date: 2009-12-07, release date: 2010-05-05, Last modification date: 2023-09-06)
Primary citation	Dutta, S.,Gulla, S.,Chen, T.S.,Fire, E.,Grant, R.A.,Keating, A.E. Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL. J.Mol.Biol., 398:747-762, 2010 Cited by PubMed: 20363230 DOI: 10.1016/j.jmb.2010.03.058 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.349 Å)

Structure validation